CAJ | 학술논문

目的研究食管癌组织中主要组织相容性复合体-Ⅰ类分子链相关蛋白A/B(MICA/B)基因蛋白的表达情况,探讨其与食管癌患者临床病理特征的关系.方法应用免疫组织化学染色方法检测40例食管癌和癌旁组织中MICA/B蛋白的表达情况,并分析其与食管癌患者临床病理特征的关系.结果 MICA/B蛋白在细胞质和细胞膜中呈阳性表达,MICA/B蛋白在食管癌组织中的阳性表达率为75.0％ (30/40),在癌旁组织中呈阴性,二者比较差异有统计学意义(P ＜0.001).MICA/B蛋白表达与食管癌组织学分级有关(P＜0.05),与食管癌患者的年龄、性别、分期、浸润深度和淋巴结转移无关(均P＞0.05).结论 MICA/B蛋白表达可能在食管癌的发生发展中起重要作用,并可作为诊断食管癌的分子标志物.
목적 연구식관암조직중주요조직상용성복합체-Ⅰ류분자련상관단백A/B(MICA/B)기인단백적표체정황,탐토기여식관암환자림상병리특정적관계.방법 응용면역조직화학염색방법검측40례식관암화암방조직중MICA/B단백적표체정황,병분석기여식관암환자림상병리특정적관계.결과 MICA/B단백재세포질화세포막중정양성표체,MICA/B단백재식관암조직중적양성표체솔위75.0％ (30/40),재암방조직중정음성,이자비교차이유통계학의의(P ＜0.001).MICA/B단백표체여식관암조직학분급유관(P＜0.05),여식관암환자적년령、성별、분기、침윤심도화림파결전이무관(균P＞0.05).결론 MICA/B단백표체가능재식관암적발생발전중기중요작용,병가작위진단식관암적분자표지물.
Objective To explore the expression of MICA/B in human esophageal cancer,and to analyze its correlation with clinicopathological features.Methods The expression of MICA/B in 40 cases of esophagus carcinoma and corresponding normal esophageal mucosa tissues were examined by immunohistochemistry.Results The positive rate of expression of MICA/B protein in the esophageal carcinoma was 75.0％ (30/40),and that in the corresponding normal esophageal mucosa was 0 (0/40).Up-regulation of MICA/B expression was found in the esophageal carcinomas.The expression of MICA/B was related with histological grade of the esophageal carcinoma (P =0.012).Conclusion MICA/B protein plays an important role in the esophageal carcinogenesis,and my become a useful molecular marker for the diagnosis of esophageal carcinoma.