CAJ | 학술논문

背景与目的:~(125)I组织间植入术主要应用于前列腺癌治疗,近来研究表明该治疗方法在其他实体肿瘤中的治疗中亦具有一定疗效.本研究拟探讨腹腔内恶性肿瘤~(125)I组织间插植放射治疗技术及近期疗效.方法:2006年2月-2009年1月本院治疗的腹腔内恶性肿瘤20例,其中肝转移灶7例,腹膜后淋巴结转移病灶8例,胰腺癌3例,直肠癌盆腔复发2例.结果:治疗结束后2个月采用CT复查评价,局部完全缓解(CR)7例,部分缓解(PR)7例,稳定(SD)3例、进展(PD)3例,总有效率(CR+PR)70%.结论:~(125)I组织间插植放射治疗是腹腔内恶性肿瘤的有效治疗方法,近期有效率高,不良反应可以接受,远期疗效仍需进一步观察.
배경여목적:~(125)I조직간식입술주요응용우전렬선암치료,근래연구표명해치료방법재기타실체종류중적치료중역구유일정료효.본연구의탐토복강내악성종류~(125)I조직간삽식방사치료기술급근기료효.방법:2006년2월-2009년1월본원치료적복강내악성종류20례,기중간전이조7례,복막후림파결전이병조8례,이선암3례,직장암분강복발2례.결과:치료결속후2개월채용CT복사평개,국부완전완해(CR)7례,부분완해(PR)7례,은정(SD)3례、진전(PD)3례,총유효솔(CR+PR)70%.결론:~(125)I조직간삽식방사치료시복강내악성종류적유효치료방법,근기유효솔고,불량반응가이접수,원기료효잉수진일보관찰.
Background and purpose: ~(125)I seeds implantation was mainly used in the treatment of prostate cancer. Recently, this technique has been used to treat other solid tumors such as lung cancer or liver cancer. The objective of this study was to evaluate the technique and effect of interstitial brachytherapy for intraperitoneal tumors. Methods: From February 2006 to January 2009, 20 patients with intraperitoneal tumors were treated with interstitial brachytherapy. The study included 7 cases with liver metastases, 8 cases with retroperitoneal lymph nodes metastases, three cases with pancreatic cancer, 2 cases with pelvic recurrence of rectal cancer. Results: All the patients received CT scan follow up 2 months after treatment. CR, PR, SD, PD were obtained in 7, 7, 3 and 3 cases, respectively. The total response rate was 70%. Conclusion: Interstitial brachtherapy is one of the effective treatments for the patients with intraperitoneal tumor. The adverse events are tolerable but the long-term benefits of this treatment method need further study.