CAJ | 학술논문

CD_4~+CD_(25)~+调节性T细胞(CD_4~+CD_(25)~+ regulatory T cells, CD_4~+CD_(25)~+ Tregs)可抑制机体对肿瘤的免疫应答,导致不利于肿瘤患者的对肿瘤的免疫耐受.以降低CD_4~+CD_(25)~+Tregs作用,增强对肿瘤的免疫应答为新策略的肿瘤免疫治疗探索已有初步进展.方法包括去除CD_4~+CD_(25)~+Tregs、单克隆抗体、蛋白分子转移、阻断Tregs的迁移和分化、逆转Tregs的分化、阻断Tregs的功能、疫/瘤苗、将Tregs调控与其他治疗模式相组合、提升抑制效应细胞的阈值.
CD_4~+CD_(25)~+조절성T세포(CD_4~+CD_(25)~+ regulatory T cells, CD_4~+CD_(25)~+ Tregs)가억제궤체대종류적면역응답,도치불리우종류환자적대종류적면역내수.이강저CD_4~+CD_(25)~+Tregs작용,증강대종류적면역응답위신책략적종류면역치료탐색이유초보진전.방법 포괄거제CD_4~+CD_(25)~+Tregs、단극륭항체、단백분자전이、조단Tregs적천이화분화、역전Tregs적분화、조단Tregs적공능、역/류묘、장Tregs조공여기타치료모식상조합、제승억제효응세포적역치.
CD_4~+CD_(25)~+ regulatory T cells(CD_4~+CD_(25)~+ Tregs) can suppress the useful immune response against tumors, which lead to immune tolerance to tumors in tumor patients. The tumor immunotherapy based on the new strategy which decreases the function of CD_4~+CD_(25)~+ Tregs and enhances the immune response against tumors has been explored. The methods were consisted of the depletion of CD_4~+CD_(25)~+Tregs, monoclonal antibodies, protein molecule transfer, blocking Tregs trafficking and differentiation, subverting Tregs differentiation, blocking Tregs effector functions, vaccine, combining Treg management with other treatment modalities and raising suppressed effector cell threshold.