CAJ | 학술논문

目的探讨丹参酮治疗乙型肝炎肝硬化代偿期的临床效果.方法选择我院2007年2月至2009年2月乙型肝炎肝硬化代偿期患者93例,按数字表法随机将上述患者分为观察组和对照组,观察组48例,对照组45例.两组均给予拉米夫定100 mg口服,1次/d,治疗时间为1年.观察组在以上治疗基础上再给予丹参酮Ⅱ磺酸钠注射液40 mL加入5%葡萄糖注射液250 mL,静脉滴注,1次/d,应用时间为8周.观察并比较治疗前后两组患者的临床表现与肝功能及肝纤维化指标变化.结果治疗后两组比较,观察组乏力、腹胀消失,脾肿大的临床表现与治疗前比较明显减少,对照组乏力、腹胀改善,脾肿大与治疗前比较轻微减少,治疗前后两组改善的差异有统计学意义(P＜0.05).观察组肝纤维化指标明显下降,对照组肝纤维化指标下降不明显,两组治疗前后临床改善的差异有统计学意义(P＜0.05).从临床疗效评定的效果看,对照组总有效率为64.3%,观察组总有效率为87.4%,两组患者总有效率比较差异有统计学意义(χ2=43.08,P＜0.05).结论在抗病毒治疗基础上应用丹参酮治疗乙型肝炎肝硬化代偿期临床治疗效果显著,值得借鉴.
목적 탐토단삼동치료을형간염간경화대상기적림상효과.방법 선택아원2007년2월지2009년2월을형간염간경화대상기환자93례,안수자표법수궤장상술환자분위관찰조화대조조,관찰조48례,대조조45례.량조균급여랍미부정100 mg구복,1차/d,치료시간위1년.관찰조재이상치료기출상재급여단삼동Ⅱ광산납주사액40 mL가입5%포도당주사액250 mL,정맥적주,1차/d,응용시간위8주.관찰병비교치료전후량조환자적림상표현여간공능급간섬유화지표변화.결과 치료후량조비교,관찰조핍력、복창소실,비종대적림상표현여치료전비교명현감소,대조조핍력、복창개선,비종대여치료전비교경미감소,치료전후량조개선적차이유통계학의의(P＜0.05).관찰조간섬유화지표명현하강,대조조간섬유화지표하강불명현,량조치료전후림상개선적차이유통계학의의(P＜0.05).종림상료효평정적효과간,대조조총유효솔위64.3%,관찰조총유효솔위87.4%,량조환자총유효솔비교차이유통계학의의(χ2=43.08,P＜0.05).결론 재항병독치료기출상응용단삼동치료을형간염간경화대상기림상치료효과현저,치득차감.
Objective To observe the clinical effect of tanshinone in treating compensated cirrhosis of hepatitis B. Methods 93 patients with compensated cirrhosis of hepatitis B in our hospital from February 2007 to February 2009were selected and divided into two groups randomly, survey group was 48 eases and control group was 45 cases. Both groups were taken lamivudine 100 mg once a day for a year, and the survey group were added with tanshinone for 8weeks. Before and after treatment, the clinical manifestations were surveyed and serum marks of liver function and liver fibrosis index were detected and compared between the two groups. Results After the treatment, the clinical symptoms and signs such as fatigue, abdominal distention, splenomegaly in the survey group were significantly improved, the clinical manifestations in control group were improved slightly, there was a statistical difference between the two groups( P ＜0.05). The declination of the liver fibrosis index in survey group was obvious, but in control group was not so obvious,there was a difference between the two groups( P ＜0.05). The clinical effects in survey group were improved significanly compared to the control group, the effective rate in control group was 64.3%, and in survey group was 87.4%, there was a statistical difference in the total effective rate between the two groups( χ2 = 43.08, P ＜ 0.05). Conclusions Tanshinone has a obviously clinical effects in treating compensated cirrhosis of hepatitis B based on the lamivudine therapy. It is worthy for the doctors to use.