中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
24期
14-17
,共4页
华法林%国际标准化比%血液凝固
華法林%國際標準化比%血液凝固
화법림%국제표준화비%혈액응고
Warfarin%International normalized ratio%Blood coagulation
目的 比较INRatio快速血凝分析仪与标准实验室静脉血测定的国际标准化比值(INR)之间的相关性和一致性,判断INRatio快速血凝分析仪检测INR的临床应用价值.方法 选择100例口服华法林患者.同时抽取静脉血及指端末梢血,分别行标准SYSMEX CA-7000全自动凝血仪INR测定及INRatio快速血凝分析仪INR测定.比较两组结果的相关性、一致性.结果 当测量INR≤5时,INRatio快速血凝分析仪和SYSMEX CA-7000全自动凝血仪之间显示了良好的相关性(r=0.898,P=0.000)；两种方法总体平均值偏倚差值为0.36,INRatio快速血凝分析仪比 SYSMEXCA-7000全自动凝血仪检测值高；通过Bland-Altman分析,两种方法INR平均值在1.60～3.50时,91.2％(62/68)的点在95％的一致性限度内,一致性良好；两种方法INR平均值＞3.50时,仅50.0％(1/2)的点在95％的一致性限度内,一致性差.结论 在治疗范围内,INRatio快速血凝分析仪检测的结果表现出与标准实验室结果良好的相关性和一致性,可以应用于临床对口服抗凝药患者INR的检测.
目的 比較INRatio快速血凝分析儀與標準實驗室靜脈血測定的國際標準化比值(INR)之間的相關性和一緻性,判斷INRatio快速血凝分析儀檢測INR的臨床應用價值.方法 選擇100例口服華法林患者.同時抽取靜脈血及指耑末梢血,分彆行標準SYSMEX CA-7000全自動凝血儀INR測定及INRatio快速血凝分析儀INR測定.比較兩組結果的相關性、一緻性.結果 噹測量INR≤5時,INRatio快速血凝分析儀和SYSMEX CA-7000全自動凝血儀之間顯示瞭良好的相關性(r=0.898,P=0.000)；兩種方法總體平均值偏倚差值為0.36,INRatio快速血凝分析儀比 SYSMEXCA-7000全自動凝血儀檢測值高；通過Bland-Altman分析,兩種方法INR平均值在1.60～3.50時,91.2％(62/68)的點在95％的一緻性限度內,一緻性良好；兩種方法INR平均值＞3.50時,僅50.0％(1/2)的點在95％的一緻性限度內,一緻性差.結論 在治療範圍內,INRatio快速血凝分析儀檢測的結果錶現齣與標準實驗室結果良好的相關性和一緻性,可以應用于臨床對口服抗凝藥患者INR的檢測.
목적 비교INRatio쾌속혈응분석의여표준실험실정맥혈측정적국제표준화비치(INR)지간적상관성화일치성,판단INRatio쾌속혈응분석의검측INR적림상응용개치.방법 선택100례구복화법림환자.동시추취정맥혈급지단말소혈,분별행표준SYSMEX CA-7000전자동응혈의INR측정급INRatio쾌속혈응분석의INR측정.비교량조결과적상관성、일치성.결과 당측량INR≤5시,INRatio쾌속혈응분석의화SYSMEX CA-7000전자동응혈의지간현시료량호적상관성(r=0.898,P=0.000)；량충방법총체평균치편의차치위0.36,INRatio쾌속혈응분석의비 SYSMEXCA-7000전자동응혈의검측치고；통과Bland-Altman분석,량충방법INR평균치재1.60～3.50시,91.2％(62/68)적점재95％적일치성한도내,일치성량호；량충방법INR평균치＞3.50시,부50.0％(1/2)적점재95％적일치성한도내,일치성차.결론 재치료범위내,INRatio쾌속혈응분석의검측적결과표현출여표준실험실결과량호적상관성화일치성,가이응용우림상대구복항응약환자INR적검측.
Objective To compare the correlation and agreement of international normalized ratio (INR) measured by INRatio coagulometer and standard laboratory venous blood measurement in order to judge the clinical application value of measuring INR by INRatio coagulometer.Methods One hundred who received warfarin were chosen randomly.Venous blood and finger capillary blood were taken simultaneously for measurement of INR by laboratory coagulation analyzer SYSMEX CA-7000 and INRatio coagulometer respectively.The correlation and agreement of INR results tested by the two methods were analyzed.Results When INR ≤5,there was a good correlation between INRatio coagulometer and laboratory coagulation analyzer SYSMEX CA-7000 (r =0.898,P =0.000).The mean bias of the two methods was 0.36 and INR measured by INRatio coagulometer were higher than those tested by laboratory coagulation analyzer SYSMEX CA-7000.By Bland-Altman,it showed a good agreement for 91.2％ (62/68) of the difference INR located 95％ the limited of agreement when the mean INR 1.60 - 3.50,and a bad agreement for only 50.0％(1/2) of the difference INR located 95％ the limited of agreement when the mean INR ＞ 3.50.Conclusions In the therapeutic range,INR measured by INRatio coagulometer shows a good correlation and agreement with INR measured by the established laboratory method.INRatio coagulometer can be used to monitor INR in the patients received oral anticoagulant therapy.
