CAJ | 학술논문

在医学研究中,针对疾病的小动物模型进行动态生物学进程的监测已成为最重要的研究方法之一.传统核医学影像测得的重要生理学参数包括血流量、生化代谢和细胞受体等.而如今,核医学已发展至双元融合的影像模式,包括SPECT-CT和PET-CT,这意味着在同一次扫描中,通过硬件对图像的融合,可得到功能学和解剖学的双重影像.该文针对SPECT-CT和PET-CT在小动物模型中的应用进行了比较,结论:针对小动物模型的PET-CT在医学研究中的应用具有很大优势,但SPECT-CT仍有着非常重要的作用,而且研究成本低.
재의학연구중,침대질병적소동물모형진행동태생물학진정적감측이성위최중요적연구방법지일.전통핵의학영상측득적중요생이학삼수포괄혈류량、생화대사화세포수체등.이여금,핵의학이발전지쌍원융합적영상모식,포괄SPECT-CT화PET-CT,저의미착재동일차소묘중,통과경건대도상적융합,가득도공능학화해부학적쌍중영상.해문침대SPECT-CT화PET-CT재소동물모형중적응용진행료비교,결론:침대소동물모형적PET-CT재의학연구중적응용구유흔대우세,단SPECT-CT잉유착비상중요적작용,이차연구성본저.
With the development of medical science, monitoring dynamic biologic processes in small-animal models of diseases has become one of the most important approaches in medical studies. Important physiologic parameters that traditionally have been characterized by nuclear medicine imaging include blood flow, biochemical metabolism, and cellular receptors. Recently, nuclear medicine has been greatly facilitated by the newer development of dual-modality integrated imaging systems (SPECT-CT and PET-CT) , which provide functional and anatomical images in the same scanning session, with the acquired images co-registered by means of the hardware. The purpose of this review is to compare SPECT-CT with PET-CT in several applications of small-animal models. Conclusicn: PET-CT for small animal modes in nledical research in the applications has great advantages, but SPECT-CT is still a very important role, and research low cost.