上海大学学报(英文版)
上海大學學報(英文版)
상해대학학보(영문판)
JOURNAL OF SHANGHAL UNIVERSITY
2003年
3期
301-304
,共4页
卢大用%陈恩鸿%曹静懿%金巍%田芳%丁健
盧大用%陳恩鴻%曹靜懿%金巍%田芳%丁健
로대용%진은홍%조정의%금외%전방%정건
probimane%free radicals%Lipoperoxidation%anticancer agent%neuraminic acid (sialic acid)%neoplasm metastasis
Lipid peroxide (LPO) plays pivotal roles in the process and development of many diseases. In this work, we studied the in-hibitory effect of probimane (Pro), a Chinese anticancer agent, on erythrocyte LPO and the interaction of Pro with sialic acids (sia).Malondialdehyde (MDA) of erythrocytes activated by hydrogen peroxide was measured. Pro was found to inhibit the product of LPOinduced by hydrogen peroxide in a non-enzyme system of both rabbit and human erythrocytes in the absence of doxorubicin. Sia werefound to enhance LPO production and the activity of N-glycolylneuraminic acid (NeuGc) was about 5 times higher than that of N-acetylneuraminic acid (5AcNeu) at equivalent concentrations. Pro inhibited the increased LPO production induced by sia and the activ-ity of Pro against LPO with 5AcNeu was almost twofold higher than that of Pro alone. It suggests that Pro be an inhibitor of LPO (freeradicals) and as a functional modulator of sia in body.
