CAJ | 학술논문

目的探讨不同剂量大豆异黄酮(SI)对前列腺增生大鼠组织形态学和超微结构的影响.方法应用丙酸睾酮诱导雄性SD大鼠前列腺增生,随机分为五组:正常对照组、模型组和3个大豆异黄酮剂量组,分别灌胃SI 60、120、240 mg/(kg·d),28 d后,光镜观察前列腺组织形态,同时结合图像分析系统检测前列腺腺体、间质的形态计量学改变,透射电镜观察前列腺细胞超微结构的变化.结果各剂量大豆异黄酮均可降低前列腺增生大鼠前列腺湿重、指数及体积,降低上皮细胞高度、腺体面积、腺体相对总体积、单位体积内腺体平均直径、平均体积、平均表面积和间质相对总体积,提高腺体数目、腺体数密度、腺体表面积/腺体体积和腺体平均曲率.结论大豆异黄酮具有抑制大鼠前列腺增生的作用.
목적 탐토불동제량대두이황동(SI)대전렬선증생대서조직형태학화초미결구적영향.방법 응용병산고동유도웅성SD대서전렬선증생,수궤분위오조:정상대조조、모형조화3개대두이황동제량조,분별관위SI 60、120、240 mg/(kg·d),28 d후,광경관찰전렬선조직형태,동시결합도상분석계통검측전렬선선체、간질적형태계량학개변,투사전경관찰전렬선세포초미결구적변화.결과 각제량대두이황동균가강저전렬선증생대서전렬선습중、지수급체적,강저상피세포고도、선체면적、선체상대총체적、단위체적내선체평균직경、평균체적、평균표면적화간질상대총체적,제고선체수목、선체수밀도、선체표면적/선체체적화선체평균곡솔.결론 대두이황동구유억제대서전렬선증생적작용.
Objective To investigate the effect of soybean isoflavone on histology and uhrastructure of benign prostatic hyperplasia in rats.Methods Male SD rats were injected subcutaneously testosterone propionate for 28 d to induce prostatic hyperplasia,and the rats were divided into 5 groups:control group,model group,and 3 test groups with SI in a dose of 60 mg/(kg·d),120 mg/(kg·d) and 240 mg/(kg·d),respectively.The wet prostate weight,prostatic index,morphological,uhrastmetural and morphometrie changes of the prostatic shndular and interstitial tissues were observed.Results The prostate wet weight,prostatic index and prostatic volumes in all dose groups were significantly lower than those in the models.In comparison with the model group,height of prostatic epithelial cells,glandular average diameters,volumes and surface areas in unit volume,as well as glandular circumferences,glandular relative total volumes and interstitial relative total volumes were all significantly decreased.Glandular counts,density,ratio of glandular surface area to volume,and glandular average curvature were all increased.Conclusions Soybean isoflavone can inhibit prostatic hyperplasia in rats.