CAJ | 학술논문

以聚[2,2′-(对氧基联苯)-5,5′-苯并咪唑](OPBI)及其磺化产物磺化聚[2,2′-(对氧基联苯)-5,5′-苯并咪唑](SOPBI)薄膜作为基体, 采用交替沉积和模拟体液(SBF)浸泡相结合的方法快速在薄膜表面沉积羟基磷灰石层. 采用选区电子衍射(SAED)和衰减全反射傅里叶变换红外光谱(ATR-FTIR)对羟基磷灰石(HA)的晶体结构进行了分析. 用扫描电子显微镜(SEM)对整个沉积过程中羟基磷灰石的形态变化进行了跟踪. 实验结果表明, SOPBI薄膜诱导HA沉积的速率明显快于OPBI薄膜. SOPBI的磺酸基团不但提供了固定Ca~(2+)的负电表面, 而且还有助于咪唑基团对Ca~(2+)的固定. 而缺失磺酸基团的OPBI在不同pH值的交替沉积溶液中的电离形式阻碍了咪唑基团对Ca~(2+)和HPO_4~(2-)的作用, 且未能在SBF浸泡过程中得到改善.
이취[2,2′-(대양기련분)-5,5′-분병미서](OPBI)급기광화산물광화취[2,2′-(대양기련분)-5,5′-분병미서](SOPBI)박막작위기체, 채용교체침적화모의체액(SBF)침포상결합적방법쾌속재박막표면침적간기린회석층. 채용선구전자연사(SAED)화쇠감전반사부리협변환홍외광보(ATR-FTIR)대간기린회석(HA)적정체결구진행료분석. 용소묘전자현미경(SEM)대정개침적과정중간기린회석적형태변화진행료근종. 실험결과표명, SOPBI박막유도HA침적적속솔명현쾌우OPBI박막. SOPBI적광산기단불단제공료고정Ca~(2+)적부전표면, 이차환유조우미서기단대Ca~(2+)적고정. 이결실광산기단적OPBI재불동pH치적교체침적용액중적전리형식조애료미서기단대Ca~(2+)화HPO_4~(2-)적작용, 차미능재SBF침포과정중득도개선.
Organic polymer coated with hydroxyapatite(HA) is an attractive material for the development of tissue repairing application. The abilities of hydroxyapatite incubation on poly [2,2′-(p-oxydiphenylene)-5,5′-bibenzimidazole](OPBI) and sulfonated poly[2,2′-(p-oxydiphenylene)-5,5′-bibenzimidazole](SOPBI) membranes were investigated with the combination of alternate soaking process and simulated body fluid(SBF) soaking methods. Hydroxyapatite phase was analyzed by SAED and ATR-FTIR method. Morphology changes of the hydroxyapatite were observed by SEM. The results show that the use of the SOPBI membranes leads to a higher hydroxyapatite formation rate than that of the OPBI membranes. The sulfonic groups of SOPBI membranes not only offer a negative charged surface to attract Ca~(2+) but also help imidazole groups to bind Ca~(2+). In comparison, OPBI membranes without sulfonic groups decrease formation ability of hydroxyapatite because protonation types of imidazole groups in alternate soaking solutions inhibit interaction between imidazole and Ca~(2+) and HPO_4~(2-), which can not be improved by the subsequent SBF soaking.