CAJ | 학술논문

目的探讨T2DM患者二甲双胍治疗后血清同型半胱氨酸(Hcy)、维生素B12(Vit B12)、叶酸(FA)水平的变化.方法 44例T2DM患者在原治疗的基础上口服二甲双胍,治疗前和治疗半年后测定血清Hcy、Vit B12、FA水平.结果口服二甲双胍半年后,血清Vit B12、FA水平下降,Hcy水平升高,其升高与二甲双胍使用剂量、Vit B12、FA下降相关.结论二甲双胍口服半年可降低T2DM患者Vit B12、FA水平,升高血清Hcy水平.
목적 탐토T2DM환자이갑쌍고치료후혈청동형반광안산(Hcy)、유생소B12(Vit B12)、협산(FA)수평적변화.방법 44례T2DM환자재원치료적기출상구복이갑쌍고,치료전화치료반년후측정혈청Hcy、Vit B12、FA수평.결과 구복이갑쌍고반년후,혈청Vit B12、FA수평하강,Hcy수평승고,기승고여이갑쌍고사용제량、Vit B12、FA하강상관.결론 이갑쌍고구복반년가강저T2DM환자Vit B12、FA수평,승고혈청Hcy수평.
Objective To determine the effects of metformin on the levels of serum homocysteine, Vit B12 and folate in patients with type 2 diabetes mellitus. Methods In 44 type 2 diabetic patients treated with metformin for half year, serum homocysteine, vitamin B12 and folate were examined at the beginning and the end of the treatment. Results Metformin significantly decreased the levels of serum Vit B12 and folate, increased the serum homocysteine, which significantly correlated with the administered amount of metformin. Conclusions In patients with type 2 diabetes, treatment with metformin reduces levels of Vit B12 and folate, increases homocysteine.