中国医药
中國醫藥
중국의약
CHINA MEDICINE
2008年
11期
676-678
,共3页
非糜烂性胃食管反流病%泮托拉唑%氟哌噻吨美利曲辛%抑郁%焦虑
非糜爛性胃食管反流病%泮託拉唑%氟哌噻噸美利麯辛%抑鬱%焦慮
비미란성위식관반류병%반탁랍서%불고새둔미리곡신%억욱%초필
Non-erosive gastrcosophageal reflux disease%Pantoprazole%Flupentixol%Depression%Anxiety
目的 观察泮托拉唑联合氟哌噻吨美利曲辛治疗伴有抑郁和/或焦虑的非糜烂性胃食管反流病(NERD)的疗效.方法 54例伴有抑郁和/或焦虑的NERD患者单盲随机分为3组:泮托拉唑组、氟哌噻吨芙利曲辛组和联合治疗组,每组18例,连续治疗6周,观察3组患者临床症状积分变化.结果 泮托拉唑组反酸缓解明显优于氟哌噻吨美利曲辛组(P＜0.01),2组胃烧灼感和胸痛的缓解无统计学意义(P＞0.05);联合治疗组能够明显缓解患者胃烧灼感、胸痛和反酸症状(P＜0.01).结论 泮托拉唑联合氟哌噻吨美利曲辛对伴有抑郁和/或焦虑的NERD有较好疗效.
目的 觀察泮託拉唑聯閤氟哌噻噸美利麯辛治療伴有抑鬱和/或焦慮的非糜爛性胃食管反流病(NERD)的療效.方法 54例伴有抑鬱和/或焦慮的NERD患者單盲隨機分為3組:泮託拉唑組、氟哌噻噸芙利麯辛組和聯閤治療組,每組18例,連續治療6週,觀察3組患者臨床癥狀積分變化.結果 泮託拉唑組反痠緩解明顯優于氟哌噻噸美利麯辛組(P＜0.01),2組胃燒灼感和胸痛的緩解無統計學意義(P＞0.05);聯閤治療組能夠明顯緩解患者胃燒灼感、胸痛和反痠癥狀(P＜0.01).結論 泮託拉唑聯閤氟哌噻噸美利麯辛對伴有抑鬱和/或焦慮的NERD有較好療效.
목적 관찰반탁랍서연합불고새둔미리곡신치료반유억욱화/혹초필적비미란성위식관반류병(NERD)적료효.방법 54례반유억욱화/혹초필적NERD환자단맹수궤분위3조:반탁랍서조、불고새둔부리곡신조화연합치료조,매조18례,련속치료6주,관찰3조환자림상증상적분변화.결과 반탁랍서조반산완해명현우우불고새둔미리곡신조(P＜0.01),2조위소작감화흉통적완해무통계학의의(P＞0.05);연합치료조능구명현완해환자위소작감、흉통화반산증상(P＜0.01).결론 반탁랍서연합불고새둔미리곡신대반유억욱화/혹초필적NERD유교호료효.
Objective To evaluate the therapeutic efficacy of flupentixol combined with pantoprazole in patients with non-erosive gastroesophgeal reflux disease companied by depression and/or anxiety.Methods Fifty-four patients were randomly divided into three groups(pantoprazole group,flupentixol group and combination group).Each patient was treated for six weeks continnously.The therapeutic efficacy was evaluated by the symptom scores.Results There were certain effects of pantoprazole or flupentixol alone treatment on the improvement of symptoms of NERD.Pantoprazol is a better for relieving acid reflux than flupentixol(P＜0.01),but no difference for relieving heartburn and substernal pain after treatment(P＞0.05);Combined treatment is a better for relieving the symptoms of NERD than pantoprazole or flupentixol treatment alone(P＜0.01).Conclusion Small-dose flupentixol combined with panto prazole show better effect on patients with NERD companied by depression and/or anxiety.
