中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2008年
5期
496-500
,共5页
李生兵%杨刚毅%李伶%李钶%齐晓娅%刘华%Guenther Boden
李生兵%楊剛毅%李伶%李鈳%齊曉婭%劉華%Guenther Boden
리생병%양강의%리령%리아%제효아%류화%Guenther Boden
糖尿病,2型%脂联素%apM1基因%多态性,单核苷酸%Meta分析%中国人群
糖尿病,2型%脂聯素%apM1基因%多態性,單覈苷痠%Meta分析%中國人群
당뇨병,2형%지련소%apM1기인%다태성,단핵감산%Meta분석%중국인군
Diabetes mellitus,type 2%Adiponectin%apM1 gene%Polymorphism,single nueleotide%Meta-analysis%Chinese population
目的 综合评价中国人群脂联素基因(apM1)单核苷酸多态性(SNP)与2型糖尿病的关系.方法 应用Meta分析软件包RevMan4.3.1对各研究结果进行数据合并,计算SNP基因型频数分布合并后OR值及其95%CI;利用Egger分析和失安全系数(Nfs<,0.05>)评估发表偏倚;对各研究结果进行不同分析模式和样本含量的敏感性分析,评价Meta分析结果的稳定性.结果 检索筛选到相关文献9篇.apM1基因的SNP45在各研究间存在显著的异质性(P<0.10).亚组分析表明apM1基因SNP45在以南方人群为对象的研究间异质性较大(P<0.01),是异质性的主要来源.apM1等位基因或基因型SNP45G和SNP45GG、SNP276G和SNP276GG在中国2型糖尿病人群的分布频率显著高于正常糖耐量组,其合并OR值(95%CI)分别为1.50[1.12,2.02]、2.15[1.53,3.02]、1.23[1.03,1.46]和1.26[1.00,1.59](均P<0.05).apM1基因型SNP45TG和SNP276GT在两组人群中的分布没有统计学意义(P>0.05).发表偏倚分析和敏感性分析结果证实上述Meta分析结果是稳定和可靠的.结论 中国人群2型糖尿病与apM1基因SNP关系密切,SNP45G和SNP276G可能是2型糖尿病的危险因素.
目的 綜閤評價中國人群脂聯素基因(apM1)單覈苷痠多態性(SNP)與2型糖尿病的關繫.方法 應用Meta分析軟件包RevMan4.3.1對各研究結果進行數據閤併,計算SNP基因型頻數分佈閤併後OR值及其95%CI;利用Egger分析和失安全繫數(Nfs<,0.05>)評估髮錶偏倚;對各研究結果進行不同分析模式和樣本含量的敏感性分析,評價Meta分析結果的穩定性.結果 檢索篩選到相關文獻9篇.apM1基因的SNP45在各研究間存在顯著的異質性(P<0.10).亞組分析錶明apM1基因SNP45在以南方人群為對象的研究間異質性較大(P<0.01),是異質性的主要來源.apM1等位基因或基因型SNP45G和SNP45GG、SNP276G和SNP276GG在中國2型糖尿病人群的分佈頻率顯著高于正常糖耐量組,其閤併OR值(95%CI)分彆為1.50[1.12,2.02]、2.15[1.53,3.02]、1.23[1.03,1.46]和1.26[1.00,1.59](均P<0.05).apM1基因型SNP45TG和SNP276GT在兩組人群中的分佈沒有統計學意義(P>0.05).髮錶偏倚分析和敏感性分析結果證實上述Meta分析結果是穩定和可靠的.結論 中國人群2型糖尿病與apM1基因SNP關繫密切,SNP45G和SNP276G可能是2型糖尿病的危險因素.
목적 종합평개중국인군지련소기인(apM1)단핵감산다태성(SNP)여2형당뇨병적관계.방법 응용Meta분석연건포RevMan4.3.1대각연구결과진행수거합병,계산SNP기인형빈수분포합병후OR치급기95%CI;이용Egger분석화실안전계수(Nfs<,0.05>)평고발표편의;대각연구결과진행불동분석모식화양본함량적민감성분석,평개Meta분석결과적은정성.결과 검색사선도상관문헌9편.apM1기인적SNP45재각연구간존재현저적이질성(P<0.10).아조분석표명apM1기인SNP45재이남방인군위대상적연구간이질성교대(P<0.01),시이질성적주요래원.apM1등위기인혹기인형SNP45G화SNP45GG、SNP276G화SNP276GG재중국2형당뇨병인군적분포빈솔현저고우정상당내량조,기합병OR치(95%CI)분별위1.50[1.12,2.02]、2.15[1.53,3.02]、1.23[1.03,1.46]화1.26[1.00,1.59](균P<0.05).apM1기인형SNP45TG화SNP276GT재량조인군중적분포몰유통계학의의(P>0.05).발표편의분석화민감성분석결과증실상술Meta분석결과시은정화가고적.결론 중국인군2형당뇨병여apM1기인SNP관계밀절,SNP45G화SNP276G가능시2형당뇨병적위험인소.
Objective To evaluate the association of apM1 gene single nucleotide polymorphisms (SNP) with type 2 diabetes mellitus in Chinese population. Methods Odds ratios (OR) of apM1 gene SNP distribution were analyzed. The Meta-analysis software (RevMan 4.3.1) was employed for summarizing the studies,calculating the pooled OR and its 95% CI and testing the overall effects. Egger's test and fail-safe number for P=0.05 (Nfs<,0.05>) were performed for evaluating the publication bias. The sensitivity analysis by different effect models and sample sizes were employed for the reliability of Meta-analysis. Results Nine literatures were obtained, apM1 gene SNP45 showed remarkable heterogeneity among the studies (P<0.10). Sub-group analysis revealed that the discrepancy based on southern Chinese individuals was the main source of the total heterogeneity.The distribution frequencies of apM1 gene SNP45G, SNP45GG, SNP276G and SNP276GG were significantly higher in Chinese type 2 diabetes mellitus group than those in NGT group (P<0.05). Their pooled OR and 95% C/were 1.50[1.12,2.02], 2.15[1.53, 3.02],1.23[1.03, 1.46] and 1.26[1.00,1.59], respectively (all P<0.05). The distribution of apM1 gene SNP45TG and SNP276GT between type 2 diabetes mellitus and normal glucose tolerance group revealed no difference among these studies. The results of publication bias diagnostics and sensitivity analysis accounted for the reliability and stability of this Meta-analysis. Conclusion apM1 gene SNPs are strongly associated with type 2 diabetes mellitus in Chinese population. SNP45G and SNP276G seem to be risk factors for type 2 diabetes mellitus.
