中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
11期
1480-1482
,共3页
肾替代疗法%烧伤,吸入性%细胞因子类
腎替代療法%燒傷,吸入性%細胞因子類
신체대요법%소상,흡입성%세포인자류
Renal replacement therapy%Burn,inhalation%Cytokines
目的 观察连续性肾脏替代疗法(CRRT)治疗严重烧伤合并吸人性化学中毒的临床疗效及对患者血液生化指标、细胞因子水平的影响.方法 60例烧伤并吸人性化学中毒患者在知情同意情况下按入院单双号随机分为治疗组和对照组各30例,对照组采用烧伤常规治疗方法,治疗组加用CRRT治疗,平均2～3次.观察比较两组临床疗效及治疗前后生化指标和细胞因子水平变化.结果 治疗组治疗后心率、动脉血氧分压、尿素氮、血肌酐水平分别为(110.0±26.0)次/min、(93.3±11.0)mm Hg、(6.1±1.3)mmol/L、(106.4±24.8)μmol/L,较治疗前的(148.0±38.0)次/min、(84.5±9.1)mm Hg、(8.6±1.9)mmoL/L、(172.6±29.8)μmol/L有明显改善(t=2.154、2.345、2.458、2.544,均P＜0.05),与对照组治疗后的(133.0±37.O)次/min、(86.5±9.9)mm Hg、(8.3±2.0)mmol/L、(134.6±26.8)μmol/L差异均有统计学意义(t=2.174、2.245、2.558、2.444,均P＜0.05);治疗组治疗后白细胞介素-1、-6、-8及肿瘤坏死因子-α水平[(260.7 ±25.9)ng/L、(327.6 ±129.2)ng/L、(300.3±146.6)ng/L、(97.1±22.3)ng/L]与对照组治疗后[(368.2±24.8)ng/L、(400.2 ±198.3)ng/L、(482.9 ±198.5)ng/L、(225.0±22.3)ng/L]差异均有统计学意义(t=2.314、2.371、2.278、2.316,均P＜0.05).结论 CRRT治疗可以清除严重烧伤患者炎性介质和细胞因子,维持内环境稳定.
目的 觀察連續性腎髒替代療法(CRRT)治療嚴重燒傷閤併吸人性化學中毒的臨床療效及對患者血液生化指標、細胞因子水平的影響.方法 60例燒傷併吸人性化學中毒患者在知情同意情況下按入院單雙號隨機分為治療組和對照組各30例,對照組採用燒傷常規治療方法,治療組加用CRRT治療,平均2～3次.觀察比較兩組臨床療效及治療前後生化指標和細胞因子水平變化.結果 治療組治療後心率、動脈血氧分壓、尿素氮、血肌酐水平分彆為(110.0±26.0)次/min、(93.3±11.0)mm Hg、(6.1±1.3)mmol/L、(106.4±24.8)μmol/L,較治療前的(148.0±38.0)次/min、(84.5±9.1)mm Hg、(8.6±1.9)mmoL/L、(172.6±29.8)μmol/L有明顯改善(t=2.154、2.345、2.458、2.544,均P＜0.05),與對照組治療後的(133.0±37.O)次/min、(86.5±9.9)mm Hg、(8.3±2.0)mmol/L、(134.6±26.8)μmol/L差異均有統計學意義(t=2.174、2.245、2.558、2.444,均P＜0.05);治療組治療後白細胞介素-1、-6、-8及腫瘤壞死因子-α水平[(260.7 ±25.9)ng/L、(327.6 ±129.2)ng/L、(300.3±146.6)ng/L、(97.1±22.3)ng/L]與對照組治療後[(368.2±24.8)ng/L、(400.2 ±198.3)ng/L、(482.9 ±198.5)ng/L、(225.0±22.3)ng/L]差異均有統計學意義(t=2.314、2.371、2.278、2.316,均P＜0.05).結論 CRRT治療可以清除嚴重燒傷患者炎性介質和細胞因子,維持內環境穩定.
목적 관찰련속성신장체대요법(CRRT)치료엄중소상합병흡인성화학중독적림상료효급대환자혈액생화지표、세포인자수평적영향.방법 60례소상병흡인성화학중독환자재지정동의정황하안입원단쌍호수궤분위치료조화대조조각30례,대조조채용소상상규치료방법,치료조가용CRRT치료,평균2～3차.관찰비교량조림상료효급치료전후생화지표화세포인자수평변화.결과 치료조치료후심솔、동맥혈양분압、뇨소담、혈기항수평분별위(110.0±26.0)차/min、(93.3±11.0)mm Hg、(6.1±1.3)mmol/L、(106.4±24.8)μmol/L,교치료전적(148.0±38.0)차/min、(84.5±9.1)mm Hg、(8.6±1.9)mmoL/L、(172.6±29.8)μmol/L유명현개선(t=2.154、2.345、2.458、2.544,균P＜0.05),여대조조치료후적(133.0±37.O)차/min、(86.5±9.9)mm Hg、(8.3±2.0)mmol/L、(134.6±26.8)μmol/L차이균유통계학의의(t=2.174、2.245、2.558、2.444,균P＜0.05);치료조치료후백세포개소-1、-6、-8급종류배사인자-α수평[(260.7 ±25.9)ng/L、(327.6 ±129.2)ng/L、(300.3±146.6)ng/L、(97.1±22.3)ng/L]여대조조치료후[(368.2±24.8)ng/L、(400.2 ±198.3)ng/L、(482.9 ±198.5)ng/L、(225.0±22.3)ng/L]차이균유통계학의의(t=2.314、2.371、2.278、2.316,균P＜0.05).결론 CRRT치료가이청제엄중소상환자염성개질화세포인자,유지내배경은정.
Objective To investigate the influence of biochemical indices and coagulation function in severe burn patients with chemical poisoning by continuous renal replacement therapy(CRRT)treatment.Methods 60 patients were randomly divided into CRRT treatment group(n=30)and basic therapy(n=30).The control group received conventional treatment,based therapies in the treatment group based on the use CRRT treatment,the average course of 2 or 3 times to observe the biochemical indicators coagulation,and cytokine before treatment compared with that after treatment.Results In treatment group,the index of heart rate,arterial partial pressure of oxygen,blood urea nitrogen,serum creatinine after treatment[(110.0±26.0)times/min,(93.3±11.0)mm Hg,(6.1 ±1.3)mmol/L,(106.4±24.8)μmol/L],compared with before treatment[(148.0±38.0)times/min、(84.5 9.1)mm Hg,(8.6±1.9)mmol/L,(172.6 ±29.8)μmol/L]were significantly different(t=2.154,2.345、2.458,2.544,all P＜0.05),and compared with control group[(133.0±37.0)times/min,(86.5 ±9.9)mm Hg,(8.3 ±2.0)mmol/L,(134.6±26.8)μmol/L]were statistically significant(t=2.174,2.245,2.558,2.444,all P＜0.05);The index of IL-1,IL-6,IL-8,TNF-α after treatment in treatment group[(260.7 ±25.9)ng/L,(327.6±129.2)ng/L,(300.3±146.6)ng/L,(97.1±22.3)ng/L)compared with control group after treatment[(368 .2±24.8)ng/L,(400.2±198.3)ng/L,(482.9±198.5)ng/L,(225.0 ±22.3)ng/L]had significant differences(t=2.314、2.371、2.278、2.316,all P＜0.05).Conclusion The treatment group of patients with severe burns could remove the inflammatory mediators and cywkines,to improve their inflammatory state and maintain stability in the environment.
