CAJ | 학술논문

精原干细胞(Spermatogonial stem cells,SSCs)是指位于睾丸曲细精管基膜上,既能自我更新以维持自身群体数量恒定,又能定向分化形成精母细胞,最终形成精子的一类成体干细胞.鉴于SSCs独具的生物学特性,其在干细胞生物学、医学、畜牧业等领域具有重要价值.通过其建立转基因动物模型,对研究精子的发生机制、重建不育个体的生精功能等有着重要意义.笔者对哺乳动物SSCs的形态特性,增殖分化特性及其调控因素,以及SSCs在畜牧业中的应用进行了综述.
정원간세포(Spermatogonial stem cells,SSCs)시지위우고환곡세정관기막상,기능자아경신이유지자신군체수량항정,우능정향분화형성정모세포,최종형성정자적일류성체간세포.감우SSCs독구적생물학특성,기재간세포생물학、의학、축목업등영역구유중요개치.통과기건립전기인동물모형,대연구정자적발생궤제、중건불육개체적생정공능등유착중요의의.필자대포유동물SSCs적형태특성,증식분화특성급기조공인소,이급SSCs재축목업중적응용진행료종술.
Spermatogonial stem cells(SSCs), which not only can maintain the number of themselves, but also can differentiate into spermatocytes, are located in seminiferous tubules.Due to their unique biological properties, investigations on SSCs are significantly important in stem cell biology, basic medicine and animal science.Using SSCs to prepare transgenic animal models has key roles in understanding the mechanism of spermatogenesis and rebuilding spermatogenic function of infertile individual.The morphological, proliferating, differentiating characteristics and the regulation of mammalian SSCs and the applications of SSCs on the stockbreeding were reviewed.