CAJ | 학술논문

目的观察大鼠发生局灶性脑梗死时脑电(EEG)参数近似熵(ApEn)的变化,探讨ApEn是否对脑梗死的发生具有监测作用.方法选择SD大鼠24只,随机分为两组:脑梗死组(n=12),线栓法阻塞右侧大脑中动脉;对照组(n=12).行颈内动脉分离、结扎,不阻塞大脑中动脉.记录梗死组在梗死前(T_0)、梗死即刻(T_1)、梗死后5、15、30、60min(T_(2～5))时大鼠脑部缺血区域(C4)和正常区域(C3)的ApEn.按相同时间点记录对照组的ApEn.结果对照组各时间点C3、C4间及假手术后与基础值相比较均无统计学差异(P>0.05).梗死组梗死前大鼠脑部C3、C4的EEG参数ApEn基本相同.梗死后,脑部C3、C4的ApEn较梗死前均升高,C4低于C3(P<0.05);ApEn随时间进行性下降;梗死后30 min时,C4的ApEn已低于梗死前的值(P<0.05).对照组C3、C4区域各个时间点的ApEn均无明显差异.两组在梗死前和假手术时的ApEn比较无明显差异.结论 ApEn可对大鼠脑部出现的单侧局灶性梗死进行监测,可能对梗死后的脑缺血程度有一定的判定作用.
목적 관찰대서발생국조성뇌경사시뇌전(EEG)삼수근사적(ApEn)적변화,탐토ApEn시부대뇌경사적발생구유감측작용.방법 선택SD대서24지,수궤분위량조:뇌경사조(n=12),선전법조새우측대뇌중동맥;대조조(n=12).행경내동맥분리、결찰,불조새대뇌중동맥.기록경사조재경사전(T_0)、경사즉각(T_1)、경사후5、15、30、60min(T_(2～5))시대서뇌부결혈구역(C4)화정상구역(C3)적ApEn.안상동시간점기록대조조적ApEn.결과 대조조각시간점C3、C4간급가수술후여기출치상비교균무통계학차이(P>0.05).경사조경사전대서뇌부C3、C4적EEG삼수ApEn기본상동.경사후,뇌부C3、C4적ApEn교경사전균승고,C4저우C3(P<0.05);ApEn수시간진행성하강;경사후30 min시,C4적ApEn이저우경사전적치(P<0.05).대조조C3、C4구역각개시간점적ApEn균무명현차이.량조재경사전화가수술시적ApEn비교무명현차이.결론 ApEn가대대서뇌부출현적단측국조성경사진행감측,가능대경사후적뇌결혈정도유일정적판정작용.
Objective To investigate the changes of EEG approximate entropy(ApEn)in rats during focal cerebral infarction.Methods Twenty-four Sparague-Dawley(SD)rats were randomly divided into infarction group(n=12)with middle cerebral aaery occlusion and sham-operated group(n=12).The EEG data(ApEn)was recorded in the bilateral areas(C3,C4)of the rats with focal cerebral infarction before the infarction and immediately and at 5,15,30,and 60 min after the infarction.The same measurement was carried out in the sham-operated group.Results In the sham-operated group,ApEn in C3 and C4 showed no obvious differences at the time points(P>0.05),but in the infarction group,ApEn in C3 and C4 increased significantly after the infarction.ApEn in the ischemic area (C4) was significantly lower than that in the non-ischemic area (C3)(P<0.05).The bilateral ApEn decreased with the passage of time.ApEn in the ischemic area(C4)was significantly lowered at 30 min after the infarction in comparison with that before infarction(P<0.05).In the sham-operated group,ApEn showed no significant difference between C3 and C4.ApEn was comparable between the two groups before the operation.Conclusion ApEn can help monitor the occurrence of focal cerebral infarction of rats,and may be used to assess the extent of cerebral ischemia after infarction.