国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2009年
2期
83-85
,共3页
信号传导%表型%上皮细胞
信號傳導%錶型%上皮細胞
신호전도%표형%상피세포
Signal transduction%Phenotype%Epithelial cells
上皮-间质转化(EMT)在胚胎发育中是一个高度保守的细胞程序,它与肿瘤的浸润转移密切相关.参与这一过程的细胞内信号转导途经主要有转化生长因子(TGF)-β途径、Rho家族激酶、Hedgehog通路、Wnt通路、Notch通路、转录因子等.
上皮-間質轉化(EMT)在胚胎髮育中是一箇高度保守的細胞程序,它與腫瘤的浸潤轉移密切相關.參與這一過程的細胞內信號轉導途經主要有轉化生長因子(TGF)-β途徑、Rho傢族激酶、Hedgehog通路、Wnt通路、Notch通路、轉錄因子等.
상피-간질전화(EMT)재배태발육중시일개고도보수적세포정서,타여종류적침윤전이밀절상관.삼여저일과정적세포내신호전도도경주요유전화생장인자(TGF)-β도경、Rho가족격매、Hedgehog통로、Wnt통로、Notch통로、전록인자등.
Eipthelial-mesenchymal transformation in embryonic development is a highly conservative procedure,It is highly correlated with tumor invasion and metastasis.Several signaling pathways are involved in the cell phenotype transition,such as TGF-β pathway,Rho kinase family,Hedgehog pathway,Wnt pathway,Notch pathway and transcription factors.
