CAJ | 학술논문

血吸虫免疫逃避机制是血吸虫抵抗宿主而得以存活的重要因素,目前较肯定的机制主要是抗原改变和免疫调节.抗原改变主要是血吸虫抗原的变异、模拟和伪装,使宿主的免疫临视功能敏感度下降;免疫调节主要是血吸虫通过合成神经分子、蛋白酶、细胞因子及其他小分子物质,阻断宿主补体的激活,抑制宿主的免疫细胞功能,从而下调宿主的免疫功能,这两种机制均有利于血吸虫在宿主体内的存活.
혈흡충면역도피궤제시혈흡충저항숙주이득이존활적중요인소,목전교긍정적궤제주요시항원개변화면역조절.항원개변주요시혈흡충항원적변이、모의화위장,사숙주적면역림시공능민감도하강;면역조절주요시혈흡충통과합성신경분자、단백매、세포인자급기타소분자물질,조단숙주보체적격활,억제숙주적면역세포공능,종이하조숙주적면역공능,저량충궤제균유리우혈흡충재숙주체내적존활.
The immune evasion of schistosome is an important factor for schistosome survival in host.At present,the mechanism of the immune evasion is known as antigenic change and immune regulation.Antigenic changes mainly include Schistosoma antigen variation,simulation and disguise,which reduce the sensitivity of host's immunologic surveillance function.The schistosome blocks host's complement activation and suppresses the host's immune cell function by synthetizing neural molecules,protease,cytokines and other small molecules,thereby down-regulates the host's immune function.Both two mechanisms are beneficial for schisto some survival in host.