中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
18期
27-29
,共3页
张引民%汪秀芹%苗凤英%邢海燕
張引民%汪秀芹%苗鳳英%邢海燕
장인민%왕수근%묘봉영%형해연
人乳头瘤病毒%意义不明的非典型鳞状细胞%低度鳞状上皮内病变
人乳頭瘤病毒%意義不明的非典型鱗狀細胞%低度鱗狀上皮內病變
인유두류병독%의의불명적비전형린상세포%저도린상상피내병변
Human papilloma virus%Atypical squamous cell of undetermined significance%Low grade squamous intraepithelial lesion
目的 探讨第二代杂交捕获试验(Hc-2)检测高危型人乳头瘤病毒(HR-HPV)DNA对细胞学结果为意义不明的非典型鳞状细胞(ASCUS)和低度鳞状上皮内病变(LSIL)的管理价值.方法 收集细胞学结果为ASCUS(178例)和LSIL(108例)的HR-HPV感染情况,以敏感度、特异度、阳性预测值和阴性预测值来评价Hc-2检测HR-HPV DNA在宫颈病变筛查中的价值.结果 Hc-2检测HR-HPV DNA对于ASCUS中病理结果为宫颈上皮内瘤变(CIN)Ⅱ及其以上级别病变的敏感度为89.83%(53/59),特异度为53.78%(64/119),阳性预测值为49 07%(53/108),阴性预测值为91.43%(64/70):对于LSIL中CIN Ⅱ及其以上级别病变的敏感度为97.62%(41/42),特异度为22.73%(15/66),阳性预测值为44.57%(41/92),阴性预测值为93.75%(15/16).结论 HR-HPV DNA检测是一种管理细胞学结果为 ASCUS和LSIL病例的有效手段.
目的 探討第二代雜交捕穫試驗(Hc-2)檢測高危型人乳頭瘤病毒(HR-HPV)DNA對細胞學結果為意義不明的非典型鱗狀細胞(ASCUS)和低度鱗狀上皮內病變(LSIL)的管理價值.方法 收集細胞學結果為ASCUS(178例)和LSIL(108例)的HR-HPV感染情況,以敏感度、特異度、暘性預測值和陰性預測值來評價Hc-2檢測HR-HPV DNA在宮頸病變篩查中的價值.結果 Hc-2檢測HR-HPV DNA對于ASCUS中病理結果為宮頸上皮內瘤變(CIN)Ⅱ及其以上級彆病變的敏感度為89.83%(53/59),特異度為53.78%(64/119),暘性預測值為49 07%(53/108),陰性預測值為91.43%(64/70):對于LSIL中CIN Ⅱ及其以上級彆病變的敏感度為97.62%(41/42),特異度為22.73%(15/66),暘性預測值為44.57%(41/92),陰性預測值為93.75%(15/16).結論 HR-HPV DNA檢測是一種管理細胞學結果為 ASCUS和LSIL病例的有效手段.
목적 탐토제이대잡교포획시험(Hc-2)검측고위형인유두류병독(HR-HPV)DNA대세포학결과위의의불명적비전형린상세포(ASCUS)화저도린상상피내병변(LSIL)적관리개치.방법 수집세포학결과위ASCUS(178례)화LSIL(108례)적HR-HPV감염정황,이민감도、특이도、양성예측치화음성예측치래평개Hc-2검측HR-HPV DNA재궁경병변사사중적개치.결과 Hc-2검측HR-HPV DNA대우ASCUS중병리결과위궁경상피내류변(CIN)Ⅱ급기이상급별병변적민감도위89.83%(53/59),특이도위53.78%(64/119),양성예측치위49 07%(53/108),음성예측치위91.43%(64/70):대우LSIL중CIN Ⅱ급기이상급별병변적민감도위97.62%(41/42),특이도위22.73%(15/66),양성예측치위44.57%(41/92),음성예측치위93.75%(15/16).결론 HR-HPV DNA검측시일충관리세포학결과위 ASCUS화LSIL병례적유효수단.
Objective To discuss the significance of high-risk human papilloma virus ( HR-HPV) detection by hybrid capture 2 (Hc-2) in managing the women with atypical squamous cell of undetermined significance (ASCIIS) and low grade squamous intraepithelial lesion (LSIL) of thin prep liquid-based cytology (TCT). Methods One hundred and seventy-eight women with ASCUS and 108 women with LSIL were studied. The infection of HR-HPV in the women was analyzed. And sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were used to evaluate the significance of HR-HPV detection by Hc-2 in managing the women with ASCUS and LSIL of TCT. Results Sensitivity,specificity, PPV and NPV of HR-HPV DNA detection by Hc-2 in screening CIN II or above in ASCUS were 89.83% (53/59),53.78% (64/119), 49.07% (53/108), 91.43% (64/70) respectively,and in LSIL were 97.62%(41/42),22.73%(15/66), 44.57%(41/92), 93.75%( 15/16) respectively. Conclusion HR-HPV detection by Hc-2 is an effective measure in managing the women with ASCUS and LSIL of TCT.
