中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2008年
24期
1690-1692
,共3页
张耀光%王建业%刘明%万奔%魏东%邓庶民%许进%伍建业%褚欣%曾平
張耀光%王建業%劉明%萬奔%魏東%鄧庶民%許進%伍建業%褚訢%曾平
장요광%왕건업%류명%만분%위동%산서민%허진%오건업%저흔%증평
良性前列腺增生%前列腺体积%前列腺特异性抗原%治疗
良性前列腺增生%前列腺體積%前列腺特異性抗原%治療
량성전렬선증생%전렬선체적%전렬선특이성항원%치료
Benign prostatic hyperplasia%Prostate volume%Prostate specific antigen%Treatment
目的 了解进入观察等待、药物治疗和手术治疗3种治疗方案的良性前列腺增生患者的主要客观指标的具体数据,分析其对治疗方案选择的影响.方法 按照试验规定的纳入和排除标准,选择初诊的良性前列腺增生患者329例,按目前泌尿外科的实际诊疗状况,将患者列入观察等待(61例)、药物治疗(179例)和手术治疗(89例)3种治疗方案组,对入组患者的前列腺体积、血清前列腺特异性抗原(PSA)、最大尿流率、平均尿流率,排尿量、残余尿指数等进行观察.结果 观察等待、药物治疗和手术治疗3种治疗方案组患者的前列腺体积(ml)均数为33.0、40.1、65.5;最大尿流率(ml/s)均数为17.1、12.4、9.1;平均尿流率(ml/s)均数为9.9、7.3、4.2;排尿量(ml)均数为332、247、188.以上指标组间差异具有统计学意义.血清前列腺特异性抗原(ng/ml)均数为1.53、1.99、5.44;残余尿量(ml)均数为21、45、208.这2种指标手术治疗组与其他2组间差异具有统计学意义,而在药物治疗和观察等待组间差异无统计学意义.结论 前列腺体积、血清前列腺特异性抗原(PSA)、最大尿流率、平均尿流率、排尿量、残余尿是良性前列腺增生症患者选择治疗方案的重要影响因素.
目的 瞭解進入觀察等待、藥物治療和手術治療3種治療方案的良性前列腺增生患者的主要客觀指標的具體數據,分析其對治療方案選擇的影響.方法 按照試驗規定的納入和排除標準,選擇初診的良性前列腺增生患者329例,按目前泌尿外科的實際診療狀況,將患者列入觀察等待(61例)、藥物治療(179例)和手術治療(89例)3種治療方案組,對入組患者的前列腺體積、血清前列腺特異性抗原(PSA)、最大尿流率、平均尿流率,排尿量、殘餘尿指數等進行觀察.結果 觀察等待、藥物治療和手術治療3種治療方案組患者的前列腺體積(ml)均數為33.0、40.1、65.5;最大尿流率(ml/s)均數為17.1、12.4、9.1;平均尿流率(ml/s)均數為9.9、7.3、4.2;排尿量(ml)均數為332、247、188.以上指標組間差異具有統計學意義.血清前列腺特異性抗原(ng/ml)均數為1.53、1.99、5.44;殘餘尿量(ml)均數為21、45、208.這2種指標手術治療組與其他2組間差異具有統計學意義,而在藥物治療和觀察等待組間差異無統計學意義.結論 前列腺體積、血清前列腺特異性抗原(PSA)、最大尿流率、平均尿流率、排尿量、殘餘尿是良性前列腺增生癥患者選擇治療方案的重要影響因素.
목적 료해진입관찰등대、약물치료화수술치료3충치료방안적량성전렬선증생환자적주요객관지표적구체수거,분석기대치료방안선택적영향.방법 안조시험규정적납입화배제표준,선택초진적량성전렬선증생환자329례,안목전비뇨외과적실제진료상황,장환자렬입관찰등대(61례)、약물치료(179례)화수술치료(89례)3충치료방안조,대입조환자적전렬선체적、혈청전렬선특이성항원(PSA)、최대뇨류솔、평균뇨류솔,배뇨량、잔여뇨지수등진행관찰.결과 관찰등대、약물치료화수술치료3충치료방안조환자적전렬선체적(ml)균수위33.0、40.1、65.5;최대뇨류솔(ml/s)균수위17.1、12.4、9.1;평균뇨류솔(ml/s)균수위9.9、7.3、4.2;배뇨량(ml)균수위332、247、188.이상지표조간차이구유통계학의의.혈청전렬선특이성항원(ng/ml)균수위1.53、1.99、5.44;잔여뇨량(ml)균수위21、45、208.저2충지표수술치료조여기타2조간차이구유통계학의의,이재약물치료화관찰등대조간차이무통계학의의.결론 전렬선체적、혈청전렬선특이성항원(PSA)、최대뇨류솔、평균뇨류솔、배뇨량、잔여뇨시량성전렬선증생증환자선택치료방안적중요영향인소.
Objective To observe different objective observation parameters of the benign prostatic hyperplasia(BPH)patients accepting different treatment strategies,and to further analyze the relationship of these factors with the treatment option．Methods Three hundred and twenty-nine BPH patients,aged 50-80,were assigned into 3 groups jointly decided by the physicians and patients based on the individual conditions and the patients'willingness:watchful waiting group(n=61),aged(63±8),drug treatment group(n=179),aged(68±7),and operation group(n=89),aged(71±6).The data of prostate volume,prostate specific antigen(PSA),maximum flow rate(Qmax),average flow rate,urinating volume,and residual urine volume before treatment were recorded.Results The prostate volume of the watchful waiting group was 33.0 ml,significantly smaller then those of the drug treatment and operation groups(40.1 and 65.5 ml respectively,both P<0.01);the Qmax of the watchful waiting group was 17.1 ml/s,significantly higher than those of the drug treatment and operation groups(12.4 and 9.1 ml/s respectively,both P<0.01).and the urinating volume of the watchful waiting group was 332 ml,significantly more than those of the drug treatment and operation groups(247 and 188 ml respectively,both P<0.01).The serum PSA of the operation group Was 5.44 ng/ml,significantly higher than those of the watchful waiting and drug treatment groups(1.53 and 1.99 ng/ml respectively,both P<0.01):and the residual urine volume of the operation group was 208 ml,significantly higher than those of the watchful waiting and drug treatment groups(21 and 45 ml respectively,both P<0.01).There were no significant differences in the serum PSA and residual urine volume between the drug treatment and watchful waiting groups.Conclusions Prostate volume,PSA,Qmax,average flow rate,urinating volume,and residual urine volume are important influential factors influencing the treatment option of BPH．Data analysis of the objective observation parameters will be helpful in clinical decision making.
