CAJ | 학술논문

放疗在肺部恶性肿瘤的治疗中有着举足轻重的作用,而放射性肺损伤是治疗过程中最主要的并发症,是阻碍患者继续进一步放疗及接受更高剂量放疗的重要因素.研究表明,间充质干细胞(MSC)具有自我复制、多向分化、免疫调节、定向迁徙等特性,能修复机体多种急慢性肺损伤,同时干细胞移植能刺激机体产生多种细胞因子有效减轻急性肺损伤,为放射性肺损伤的防治研究提供新思路.
방료재폐부악성종류적치료중유착거족경중적작용,이방사성폐손상시치료과정중최주요적병발증,시조애환자계속진일보방료급접수경고제량방료적중요인소.연구표명,간충질간세포(MSC)구유자아복제、다향분화、면역조절、정향천사등특성,능수복궤체다충급만성폐손상,동시간세포이식능자격궤체산생다충세포인자유효감경급성폐손상,위방사성폐손상적방치연구제공신사로.
Radiotherapy plays a significant role in the treatment of lung malignant tumor.However,as the most main complication of radiotherapy used to treat lung malignant tumor,radiation-induced lung injury is an important influencing factor in impeding further and higher dose radiotherapy.Previous studies show that mesenchymal stem cells (MSCs) have the characteristics of self-replication,multiple differentiation,immunoregulation and directional migration. MSCs can help to repair many kinds of acute and chronic lung injury,meanwhile stem cell transplantation stimulates production of many cytokines to attenuate acute lung injury.So stem cell therapy provides a new kind of thinking in the prevention and treatment of radiation-induced lung injury.