CAJ | 학술논문

目的比较介入栓塞术与开颅术治疗脑动脉瘤临床疗效.方法 60例脑动脉瘤破裂的患者采用随机数字表法平均分为两组各30例,A组给予介入栓塞术治疗,B组给予开颅手术治疗.随访观察3个月,记录有无再出血,并采用Glasgow结果评分评价,同时检测治疗前后基质金属蛋白酶-2(MMP-2)水平变化及住院时间.结果治疗后,A组治疗总有效率73.4％、术后再出血率10.0％ (3/30),B组分别为76.7％、6.7％ (2/30),两组差异均无统计学意义(x2=0.09、0.22,均P＞0.05);两组治疗前MMP-2水平差异无统计学意义(t=1.21,P＞0.05);两组手术治疗后3 d MMP-2水平分别为(20.1±8.7) μg/L、(35.7±8.9) μg/L,两组差异有统计学意义(t =3.33,P＜0.05).A组住院时间(8.6±1.5)d,B组为(13.2±1.3)d,两组差异有统计学意义(t =3.18,P＜0.05).结论对于脑动脉瘤破裂的患者,采用介入栓塞术治疗与开颅术疗效无明显差异,但可减少住院时间,且明显降低MMP-2水平.
목적 비교개입전새술여개로술치료뇌동맥류림상료효.방법 60례뇌동맥류파렬적환자채용수궤수자표법평균분위량조각30례,A조급여개입전새술치료,B조급여개로수술치료.수방관찰3개월,기록유무재출혈,병채용Glasgow결과평분평개,동시검측치료전후기질금속단백매-2(MMP-2)수평변화급주원시간.결과 치료후,A조치료총유효솔73.4％、술후재출혈솔10.0％ (3/30),B조분별위76.7％、6.7％ (2/30),량조차이균무통계학의의(x2=0.09、0.22,균P＞0.05);량조치료전MMP-2수평차이무통계학의의(t=1.21,P＞0.05);량조수술치료후3 d MMP-2수평분별위(20.1±8.7) μg/L、(35.7±8.9) μg/L,량조차이유통계학의의(t =3.33,P＜0.05).A조주원시간(8.6±1.5)d,B조위(13.2±1.3)d,량조차이유통계학의의(t =3.18,P＜0.05).결론 대우뇌동맥류파렬적환자,채용개입전새술치료여개로술료효무명현차이,단가감소주원시간,차명현강저MMP-2수평.
Objective To compare of intervention embolization and operation in the treatment of brain aneurysms.Methods 60 cerebral aneurysm patients using random number table method were divided into two groups each 30 cases,group A given intervention embolization;group B given surgical operation treatment.They were followed for 3months,the bleed Glasgow results score,matrix metalloproteinases 2(MMP-2) level change and the length of time were recorded.Results After treatment,A group total effective rate was 73.4％,postoperative treatment to bleed again rate was 10.0％ (3/30),B group was 76.7％,6.7％ (2/30),two groups had no statistically significant differences (x2 =0.09,0.22,all P ＞ 0.05 ) before treatment M MP-2 level between ;The two groups was statistically significant ( t =1.21,P ＞ 0.05 ) ;Two groups after surgical treatment 3 d MMP-2 levels were ( 20.1 ± 8.7 ) μg/L,( 35.7 ±8.9 ) μg/L respectively,which was statistically significant ( t =3.33,P ＜ 0.05 ).A group of hospitalization time (8.6 ±1.5 ) d,group B ( 13.2 ± 1.3 ) d,the difference between two groups was statistically significant ( t =3.18,P ＜ 0.05 ).Conclusion For brain aneurysm patients,the intervention embolization had no obvious difference in curative effect with operation,but could reduce the time in hospital and significantly reduced MMP-2 level.