中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2011年
7期
608-610
,共3页
早期干预%缺氧缺血性脑病%S100B蛋白%智力发育
早期榦預%缺氧缺血性腦病%S100B蛋白%智力髮育
조기간예%결양결혈성뇌병%S100B단백%지력발육
Early intervention%Hypoxic ischemic encephalopathy%S100B%Mental developmental
目的 探讨早期综合干预对新生儿缺氧缺血性腩病(HIE)神经行为的影响及与血清SIOOB蛋白的关系.方法 将120例HIE患儿随机分为对照组和干预组,干预组在药物治疗的基础上,给予各种感知觉刺激、视听刺激、主动及被动肢体训练等早期综合干预,对照组只给予药物治疗.采用婴幼儿智力发育量表测智力发育指数(mental developmental index,MDI)和运动发育指数(psychomotor developmental index,PDI)分别在干预后3,6,12,18个月进行测定.采用酶联免疫法检测S100B蛋白水平.结果 干预组HIE患儿MDI评分从12个月开始,明显高于对照组,差异有显著性[12个月:干预组(96.6±9.4)分,对照组(86.8±9.5)分,P<0.01].干预组HIE患儿PDI评分从6个月开始,明显高于对照组,差异有显著性[6个月:干预组(91.6±9.2)分,对照组(82.2±11.0)分,P<0.01].两组HIE患儿随着月龄的增长,血清S100B蛋白的水平有下降韵趋势.在出生后两组患儿血清S100B蛋白水平较高,且没有差异(P>0.05);从3个月开始,干预组患儿的血清S100B蛋白水平降低较明显,与对照组比较,各时间点的水平差异有显著性[3个月:干预组(1.29±0.15)ng/L,对照组(1.40±0.14)ng/L;6个月:干预组(1.06±0.21)ng/L,对照组(1.26±0.22)ng/L,P<0.05,P<0.01].结论 早期综合干预能够改善HIE患儿的智力和运动发育,血清S100B蛋白是可能的机制之一.
目的 探討早期綜閤榦預對新生兒缺氧缺血性腩病(HIE)神經行為的影響及與血清SIOOB蛋白的關繫.方法 將120例HIE患兒隨機分為對照組和榦預組,榦預組在藥物治療的基礎上,給予各種感知覺刺激、視聽刺激、主動及被動肢體訓練等早期綜閤榦預,對照組隻給予藥物治療.採用嬰幼兒智力髮育量錶測智力髮育指數(mental developmental index,MDI)和運動髮育指數(psychomotor developmental index,PDI)分彆在榦預後3,6,12,18箇月進行測定.採用酶聯免疫法檢測S100B蛋白水平.結果 榦預組HIE患兒MDI評分從12箇月開始,明顯高于對照組,差異有顯著性[12箇月:榦預組(96.6±9.4)分,對照組(86.8±9.5)分,P<0.01].榦預組HIE患兒PDI評分從6箇月開始,明顯高于對照組,差異有顯著性[6箇月:榦預組(91.6±9.2)分,對照組(82.2±11.0)分,P<0.01].兩組HIE患兒隨著月齡的增長,血清S100B蛋白的水平有下降韻趨勢.在齣生後兩組患兒血清S100B蛋白水平較高,且沒有差異(P>0.05);從3箇月開始,榦預組患兒的血清S100B蛋白水平降低較明顯,與對照組比較,各時間點的水平差異有顯著性[3箇月:榦預組(1.29±0.15)ng/L,對照組(1.40±0.14)ng/L;6箇月:榦預組(1.06±0.21)ng/L,對照組(1.26±0.22)ng/L,P<0.05,P<0.01].結論 早期綜閤榦預能夠改善HIE患兒的智力和運動髮育,血清S100B蛋白是可能的機製之一.
목적 탐토조기종합간예대신생인결양결혈성남병(HIE)신경행위적영향급여혈청SIOOB단백적관계.방법 장120례HIE환인수궤분위대조조화간예조,간예조재약물치료적기출상,급여각충감지각자격、시은자격、주동급피동지체훈련등조기종합간예,대조조지급여약물치료.채용영유인지력발육량표측지력발육지수(mental developmental index,MDI)화운동발육지수(psychomotor developmental index,PDI)분별재간예후3,6,12,18개월진행측정.채용매련면역법검측S100B단백수평.결과 간예조HIE환인MDI평분종12개월개시,명현고우대조조,차이유현저성[12개월:간예조(96.6±9.4)분,대조조(86.8±9.5)분,P<0.01].간예조HIE환인PDI평분종6개월개시,명현고우대조조,차이유현저성[6개월:간예조(91.6±9.2)분,대조조(82.2±11.0)분,P<0.01].량조HIE환인수착월령적증장,혈청S100B단백적수평유하강운추세.재출생후량조환인혈청S100B단백수평교고,차몰유차이(P>0.05);종3개월개시,간예조환인적혈청S100B단백수평강저교명현,여대조조비교,각시간점적수평차이유현저성[3개월:간예조(1.29±0.15)ng/L,대조조(1.40±0.14)ng/L;6개월:간예조(1.06±0.21)ng/L,대조조(1.26±0.22)ng/L,P<0.05,P<0.01].결론 조기종합간예능구개선HIE환인적지력화운동발육,혈청S100B단백시가능적궤제지일.
Objective To investigate the early comprehensive intervention on neonatal hypoxic ischemic encephalopathy (HIE) effects and the biological mechanisms.Methods 120 cases of HIE were randomly divided into intervention group and control group.Under the basis of drug treatment,the intervention group were given the different perceptual stimuli,audiovisual stimulation,active and passive limb training early comprehensive intervention,the control group only to normal drug treatment.The mental development index(MDI) and psychomotor develo pmental index (PDI) were applied after 3,6,12,and 18 months.S100B protein levels were detected using enzyme immunoassay.Results MDI score in the intervention group with HIE,from the beginning of the 12 month,was higher than that in the control group,there was significant differences (12th month:(96.6±9.4)vs (86.8±9.5),P<0.01).PDI score from the beginning of the 6 month,was higher in the intervention group with HIE than that in the control group,there were significant differences (6th month:(91.6±9.2)vs (82.2±11.0),P<0.01).Serum S100B protein level has a tendency to fall for all HIE patients with the old growth.Born in two groups of serum S100B protein levels were higher in neonate period,but there was no difference(P>0.05).From the beginning of the 3rd month,serum S100B protein levels in the intervention group were reduced significandy,compared with the control group at each time point level(3rd month:(1.29±0.15)ng/L vs(1.40±0.14)ns/L;6th month:(1.06±0.21)ng/L vs(1.26±0.22)ng/L,P<0.01).Conclusion Early intervention can improve the mental and motor development of children with HIE,and serum S100B protein is involved in the mechanisms.
