中华航空航天医学杂志
中華航空航天醫學雜誌
중화항공항천의학잡지
CHINESE JOURNAL OF AEROSPACE MEDICINE
2010年
3期
189-191
,共3页
罗惠兰%陈勇胜%耿喜臣%孙津津%李玉茜
囉惠蘭%陳勇勝%耿喜臣%孫津津%李玉茜
라혜란%진용성%경희신%손진진%리옥천
加速度%兔%C 反应蛋白质%主动脉%血管内膜%危险性评估
加速度%兔%C 反應蛋白質%主動脈%血管內膜%危險性評估
가속도%토%C 반응단백질%주동맥%혈관내막%위험성평고
Acceleration%Rabbits%C-reactive protein%Aorta%Tunica intima%Risk assessment
目的 探讨重复正加速度(+Gz)暴露时兔血清超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)的变化与心血管损伤风险预测的关系. 方法 将24只动脉粥样硬化实验兔随机分为对照组和+Gz暴露4周、8周、12周组,每组4只.各组兔实验结束后留取静脉血,测定hs-CRP含量,并用电镜观察兔主动脉组织切片. 结果 +Gz暴露对兔静脉血hs-CRP含量的影响差异有统计学意义(F+Gz(1,23)=22.37,P=0.0001);但暴露时间对兔hs-CRP含量不产生影响(F暴露时间(1,23)=0.82,P=0.4550);+Gz暴露与持续时间之间的交互效应对hs-CRP表达量的影响差异无统计学意义(F+Gz×暴露时间(1,1)=1.10,P=0.3540).主动脉电镜观察结果 也给予支持. 结论 重复、长期+Gz暴露可致兔血清hs-CRP长期处于高水平状态,提示应重视飞行员心血管损伤风险的预测.
目的 探討重複正加速度(+Gz)暴露時兔血清超敏C反應蛋白(high-sensitivity C-reactive protein,hs-CRP)的變化與心血管損傷風險預測的關繫. 方法 將24隻動脈粥樣硬化實驗兔隨機分為對照組和+Gz暴露4週、8週、12週組,每組4隻.各組兔實驗結束後留取靜脈血,測定hs-CRP含量,併用電鏡觀察兔主動脈組織切片. 結果 +Gz暴露對兔靜脈血hs-CRP含量的影響差異有統計學意義(F+Gz(1,23)=22.37,P=0.0001);但暴露時間對兔hs-CRP含量不產生影響(F暴露時間(1,23)=0.82,P=0.4550);+Gz暴露與持續時間之間的交互效應對hs-CRP錶達量的影響差異無統計學意義(F+Gz×暴露時間(1,1)=1.10,P=0.3540).主動脈電鏡觀察結果 也給予支持. 結論 重複、長期+Gz暴露可緻兔血清hs-CRP長期處于高水平狀態,提示應重視飛行員心血管損傷風險的預測.
목적 탐토중복정가속도(+Gz)폭로시토혈청초민C반응단백(high-sensitivity C-reactive protein,hs-CRP)적변화여심혈관손상풍험예측적관계. 방법 장24지동맥죽양경화실험토수궤분위대조조화+Gz폭로4주、8주、12주조,매조4지.각조토실험결속후류취정맥혈,측정hs-CRP함량,병용전경관찰토주동맥조직절편. 결과 +Gz폭로대토정맥혈hs-CRP함량적영향차이유통계학의의(F+Gz(1,23)=22.37,P=0.0001);단폭로시간대토hs-CRP함량불산생영향(F폭로시간(1,23)=0.82,P=0.4550);+Gz폭로여지속시간지간적교호효응대hs-CRP표체량적영향차이무통계학의의(F+Gz×폭로시간(1,1)=1.10,P=0.3540).주동맥전경관찰결과 야급여지지. 결론 중복、장기+Gz폭로가치토혈청hs-CRP장기처우고수평상태,제시응중시비행원심혈관손상풍험적예측.
Objective To investigate the repeated and long-term +Gz exposure caused highsensitivity C-reactive protein (hs-CRP) changes in rabbit's serum and find its indication for predicting cardiovascular risk. Methods Twenty-four male rabbits were randomly and averagely divided into 4-week-exposure group, 8-week-exposure group, 12-week-exposure group and 3 control groups that corresponding to 4, 8 and 12 weeks tests. Rabbits were exposed under +Gz 3 times a day with 5 min interval and exposures were repeated 3 times a week. The G load was started form +4 Gz for 20 s with 1 G/s onset rate at first week. Then the G level and duration increased by 0. 5 Gz and 5 s per week until +6 Gz and 40 s reached. When last exposure finished venous blood of rabbits was collected and hs-CRP was measured. Results Compared with control groups the effects of +Gz exposure on hs-CRP content were significant (F+Gz(1,23) = 22.37, P= 0. 0001) but on duration (Fduration(1,23) =0. 82,P=0.4550). The interact effects between +Gz exposure and duration on hs-CRP content were insignificant (F+G×duration(1,23) = 1.10, P= 0. 3540). What the microscope observed proved the statistic analysis. Conclusions Repeated and long-term +Gz exposure would lead to high serum hs-CRP content in rabbit. It implies that such change may be used for predicting cardiovascular risk and be hopefully applied for pilot.