CAJ | 학술논문

支气管哮喘(简称哮喘)是由多种细胞(如嗜酸粒细胞、肥大细胞、淋巴细胞、中性粒细胞、气道上皮细胞等)和细胞组分参与的气道慢性炎症性疾病,是遗传易感个体与各种环境因素共同作用的结果.研究发现,Toll-样受体(TLR)和免疫细胞在哮喘的发生发展中起着重要作用.TLR通过识别多种病原体,激活Th1或Th2等免疫反应,被认为是防止或促进哮喘发生一个的重要因素.本文对TLR及其相关配体在哮喘发病机制中的作用作以下综述,为哮喘的治疗提供新思路.
지기관효천(간칭효천)시유다충세포(여기산립세포、비대세포、림파세포、중성립세포、기도상피세포등)화세포조분삼여적기도만성염증성질병,시유전역감개체여각충배경인소공동작용적결과.연구발현,Toll-양수체(TLR)화면역세포재효천적발생발전중기착중요작용.TLR통과식별다충병원체,격활Th1혹Th2등면역반응,피인위시방지혹촉진효천발생일개적중요인소.본문대TLR급기상관배체재효천발병궤제중적작용작이하종술,위효천적치료제공신사로.
The bronchial asthma (asthma) is a chronic inflammatory airway disease characterized by celelular component and infiltration into the airway submucosa of cells, which contain eosinophils,labrocytes,lymphocytes, neutrophils and epitheliums. Asthma is result from the contribution of genetically susceptible individuals and the various environmental stimuli. Studies have examined the contribution of toll-like receptors (TLR) and immunocells to the development of asthma. Through identifying the various micro-organisms,TLR may be involved in mechanisms provoking Thl-or Th2-biased immune responses and may, therefore, be an important factor in either preventing or promoting asthma. This review will explore the relation between TLR and asthma,provide a new idea of therapeutic effect to asthma.