CAJ | 학술논문

目的研究慢性心力衰竭(心衰)患者肾功能恶化的危险因素及其对预后的影响.方法采用病例对照研究方法,分析与肾功能恶化发生有统计学关联的独立危险因素,同时观察肾功能恶化对预后的影响.结果住院心衰患者肾功能恶化发生率31%,入院肌酐水平及心功能分级与肾功能恶化的发生独立相关,OR值分别为2.248(95%CI1.088～4.647,P=0.029)和2.485(95%CI1.385～4.459.P＝0.002).发生肾功能恶化的患者住院期间病死率明显高于对照组(16.7%比2.1%,P=0.000),调整混杂因素后,肾功能恶化是死亡的独立危险因素,OR值3.824(95%CI2.452～5.137.P＜0.015).结论肾功能恶化在住院心衰患者中发生率较高,与住院期间病死率明显相关.入院肌酐水平偏高及心功能差为发生肾功能恶化的独立危险因素.
목적 연구만성심력쇠갈(심쇠)환자신공능악화적위험인소급기대예후적영향.방법 채용병례대조연구방법,분석여신공능악화발생유통계학관련적독립위험인소,동시관찰신공능악화대예후적영향.결과 주원심쇠환자신공능악화발생솔31%,입원기항수평급심공능분급여신공능악화적발생독립상관,OR치분별위2.248(95%CI1.088～4.647,P=0.029)화2.485(95%CI1.385～4.459.P＝0.002).발생신공능악화적환자주원기간병사솔명현고우대조조(16.7%비2.1%,P=0.000),조정혼잡인소후,신공능악화시사망적독립위험인소,OR치3.824(95%CI2.452～5.137.P＜0.015).결론 신공능악화재주원심쇠환자중발생솔교고,여주원기간병사솔명현상관.입원기항수평편고급심공능차위발생신공능악화적독립위험인소.
Objective To investigate the risk factors of worsening renal function (WRF) in patients with chronic heart failure ( CHF) and WRF influence on prognosis. Methods A case-control study were undertaken to analyze independent risk factor statistically related to incidence of WRF, and to assess the influence of WRF on prognosis. Results The independent predictors of WRF were creatinine level at admission (OR 2.248,95% CI 1.088-4.647, P = 0.029) and NYHA class on admission ( OR 2.485, 95% CI 1.3854. 459, P = 0.002). The mortality of patient with WRF was obviously higher than that of control group during hospitalization( OR 3. 824,95% CI 2. 452-5. 637 ,P ＜0.015). Conclusions WRF is a common complication among patients hospitalized for CHF, and is obviously associated with mortality during hospitalization. Higher creatinine level and weak heart function are independent risk factors for incidence of WRF of patients with CHF.