CAJ | 학술논문

目的提高对淋巴结生发中心进行性转化(PTGC)的认识,探讨其临床特征、组织病理学和免疫组织化学特点及其与生发中心增生的相关疾病的鉴别诊断并对相关文献进行复习.方法报告1例淋巴结生发中心进行性转化患者的临床特征和实验室检查指标及诊治经过.结果患者主要表现为无痛性外周淋巴结肿大,病理组织学表现为滤泡增生,出现进行性转化的生发中心,生发中心和套区淋巴细胞边界不清.免疫组织化学检查示转化的生发中心细胞CD20~+、CD5~+、CDw75~+.结论 PTGC是一种临床少见的淋巴结病,组织病理学和免疫组织化学辅助检查是其诊断的重要依据.
목적 제고대림파결생발중심진행성전화(PTGC)적인식,탐토기림상특정、조직병이학화면역조직화학특점급기여생발중심증생적상관질병적감별진단병대상관문헌진행복습.방법 보고1례림파결생발중심진행성전화환자적림상특정화실험실검사지표급진치경과.결과 환자주요표현위무통성외주림파결종대,병리조직학표현위려포증생,출현진행성전화적생발중심,생발중심화투구림파세포변계불청.면역조직화학검사시전화적생발중심세포CD20~+、CD5~+、CDw75~+.결론 PTGC시일충림상소견적림파결병,조직병이학화면역조직화학보조검사시기진단적중요의거.
Objective To improve the understanding of progressive transformation of lymph node germinal centers (PTGC) and to explore its clinical, histopathologic and immunohistoohemical features and the differential diagnosis between the related disease of germinal center hyperplasia.Methods The clinical manifestation, laboratory bindings, treatment and outcome of a patient with PTGC were presented.Results The main manifestation of the patient was painless peripheral lymphadenopathy.Histopathologic examination of an axillary lymph node showed reactive follicular hyperplasia and the progressive transformation changes germinal centers.The borderline between the germinal center and the mantle layer was obscured.The cells in the progressive transforming germinal centers were positive for CD20~+、CD5~+、CDw75~+.Conclusion FFGC is a rare lymphoid disorder.Histopathology and immunohistochemistry are important basis of the diagnosis.