中华血液学杂志
中華血液學雜誌
중화혈액학잡지
Chinese Journal of Hematology
2011年
2期
112-114
,共3页
吴立华%张彦%黄平平%李尚珠%赵英新%龙凤雷%付仁敏%郑亚丽%刘春华%刘庆国%李君凡%胡依民%徐宁
吳立華%張彥%黃平平%李尚珠%趙英新%龍鳳雷%付仁敏%鄭亞麗%劉春華%劉慶國%李君凡%鬍依民%徐寧
오립화%장언%황평평%리상주%조영신%룡봉뢰%부인민%정아려%류춘화%류경국%리군범%호의민%서저
单个核细胞%造血干细胞%内皮祖细胞%造血干细胞移植%缺血
單箇覈細胞%造血榦細胞%內皮祖細胞%造血榦細胞移植%缺血
단개핵세포%조혈간세포%내피조세포%조혈간세포이식%결혈
Mononuclear cells%Hematopoietic stem cell%Endothelial progenitor cells%Hematopoietic stem cell transplatation%Ischemia
目的 分析59例下肢缺血性疾病患者进行自体外周血单个核细胞(MNC)移植的疗效及其与移植MNC数及CD34+细胞数的相关性,探索外周血MNC在下肢动脉缺血性疾病治疗中的优势.方法 对59例患者治疗前静息痛、冷感、间歇性跛行及组织损伤分别进行评分,而后动员并采集自体外周血MNC,于缺血下肢多位点等间距注射.评价治疗后第7天及4个月时的治疗效果,分析注入的MNC数及其中所含CD34+细胞数与疗效的相关性.结果 MNC移植后第7天及4个月时患者的下肢缺血均有不同程度的改善,CD34+细胞数量与疗效的相关系数为0.461(P=0.047),尼莫地平值=0.484+1.055×CD34+细胞数,MNC数量与疗效的相关系数为0.473(P=0.000),尼莫地平值=0.288+0.401×MNC数.结果 显示MNC数量比CD34+细胞数量与疗效的相关性更强.结论 注入的自体外周血MNC数较CD34+细胞数更能反映与临床疗效的相关性.
目的 分析59例下肢缺血性疾病患者進行自體外週血單箇覈細胞(MNC)移植的療效及其與移植MNC數及CD34+細胞數的相關性,探索外週血MNC在下肢動脈缺血性疾病治療中的優勢.方法 對59例患者治療前靜息痛、冷感、間歇性跛行及組織損傷分彆進行評分,而後動員併採集自體外週血MNC,于缺血下肢多位點等間距註射.評價治療後第7天及4箇月時的治療效果,分析註入的MNC數及其中所含CD34+細胞數與療效的相關性.結果 MNC移植後第7天及4箇月時患者的下肢缺血均有不同程度的改善,CD34+細胞數量與療效的相關繫數為0.461(P=0.047),尼莫地平值=0.484+1.055×CD34+細胞數,MNC數量與療效的相關繫數為0.473(P=0.000),尼莫地平值=0.288+0.401×MNC數.結果 顯示MNC數量比CD34+細胞數量與療效的相關性更彊.結論 註入的自體外週血MNC數較CD34+細胞數更能反映與臨床療效的相關性.
목적 분석59례하지결혈성질병환자진행자체외주혈단개핵세포(MNC)이식적료효급기여이식MNC수급CD34+세포수적상관성,탐색외주혈MNC재하지동맥결혈성질병치료중적우세.방법 대59례환자치료전정식통、랭감、간헐성파행급조직손상분별진행평분,이후동원병채집자체외주혈MNC,우결혈하지다위점등간거주사.평개치료후제7천급4개월시적치료효과,분석주입적MNC수급기중소함CD34+세포수여료효적상관성.결과 MNC이식후제7천급4개월시환자적하지결혈균유불동정도적개선,CD34+세포수량여료효적상관계수위0.461(P=0.047),니막지평치=0.484+1.055×CD34+세포수,MNC수량여료효적상관계수위0.473(P=0.000),니막지평치=0.288+0.401×MNC수.결과 현시MNC수량비CD34+세포수량여료효적상관성경강.결론 주입적자체외주혈MNC수교CD34+세포수경능반영여림상료효적상관성.
Objective To analyze the efficacy and its correlation with species of transplant cells of autologous mobilized peripheral blood(PB) mononucleated cells (MNCs) transplantation on 59 patients with lower limbs ischemia. Methods Fifty-nine patients were evaluated with symptoms scores and after that their PBMNCs were mobilized and collected and then injected into the ischemic area at equal distance. They effectiveness and scores were evaluated at 7th day and 4th month after therapy. The correlation of CD34 + cells and of MNCs with effectiveness was analysed respectively, and formula for c orrelations between them and effectiveness was calculated. Results After MNCs injection, the effectiveness was observed both at 7th day and 4th month . The correlation of MNCs with effectiveness was stronger than that of CD34 + cells ( the effectiveness was represented by nimodipine value), According to the formula of nimodipine value, the value of the latter =0.484 + 1. 055 × CD34 + cells number and the former = 0.288 + 0. 401 × MNCs number with a correlation coefficient of R =0. 461( P =0. 047 ) and R =0. 473 ( P =0. 000 ) respectively. Conclusion Autologous mobilized PBMNCs number is a better indicator for effectiveness than CD34 + cells number.
