中华血液学杂志
中華血液學雜誌
중화혈액학잡지
Chinese Journal of Hematology
2009年
5期
298-302
,共5页
李业楠%邹德慧%顾敏%赵耀中%齐军元%秘营昌%王建祥%邱录贵
李業楠%鄒德慧%顧敏%趙耀中%齊軍元%祕營昌%王建祥%邱錄貴
리업남%추덕혜%고민%조요중%제군원%비영창%왕건상%구록귀
费城染色体%白血病,淋巴细胞,急性%细胞遗传学分析%预后
費城染色體%白血病,淋巴細胞,急性%細胞遺傳學分析%預後
비성염색체%백혈병,림파세포,급성%세포유전학분석%예후
Philadelphia chromosome%Leukaemia,lymphoblastie,acute%Cytogenetics analy-sis%Prognosis
目的 分析成人Ph染色体和(或)bc-abl阳性(Ph+/bor-abl+)急性淋巴细胞白血病(ALL)患者细胞遗传学改,变的特点,探讨其对预后的影响.方法 回顾性分析1996年1月至2007年12月就诊并行染色体检杏的100例成人Ph+/bcr-abl+ALL.患者的临床资料,总结其染色体畸变的类型、分布和频牢特点,并进行分组研究,探讨不同组之间的临床特点及预后差异.结果 ①72例检出染色体异常,22例为单纯Ph染色体阳性或其变异型,44例Ph阳性伴附加染色体异常,常见的异常有+Ph、-7、+21、-20、+8、9p-、del(22)等.②染色体数目分组比较:假二倍体组和高二倍体组初诊时白细胞计数明显高于正常核型组,而正常核型组总生存(OS)率较业二倍体和假二倍体组高,无复发生存(RFS)期较亚二倍体和假二倍体组长.③染色体畸变类型分组比较:Ph阳性组初诊时白细胞计数明显高于Ph阴性组,而OS率较Ph阴性组低,RFS期较Ph阴性组短;单纯Ph阳性组与Ph阳性伴附加染色体异常组在临床特征、OS率和RFS期间的差异均无统计学意义.同时Ph阳性伴附加染色体异常组的OS期和RFS期也明显短于Ph阴性组.④核型分组比较:全部核型正常组(NN)患者较正常与异常核型共存组(AN)年龄轻,初诊时白细胞计数低,融合基因表达以P190为主,髓系抗原表达率高,RFS率和OS率高;NN组较全部核型异常组(AA)初诊时白细胞计数低,髓外浸润重,RFS率和OS率高.而AA与AN组之间各项差异均无统计学意义.⑤双Ph染色体组融合基因P190比例低于非双Ph染色体组,OS期短于非双Ph染色体组.结论 成人Ph+/bcr-abl+ALL患者染色体改变复杂,假二倍体和高二倍体提示预后不良,双Ph染色体可能提示预后不良.
目的 分析成人Ph染色體和(或)bc-abl暘性(Ph+/bor-abl+)急性淋巴細胞白血病(ALL)患者細胞遺傳學改,變的特點,探討其對預後的影響.方法 迴顧性分析1996年1月至2007年12月就診併行染色體檢杏的100例成人Ph+/bcr-abl+ALL.患者的臨床資料,總結其染色體畸變的類型、分佈和頻牢特點,併進行分組研究,探討不同組之間的臨床特點及預後差異.結果 ①72例檢齣染色體異常,22例為單純Ph染色體暘性或其變異型,44例Ph暘性伴附加染色體異常,常見的異常有+Ph、-7、+21、-20、+8、9p-、del(22)等.②染色體數目分組比較:假二倍體組和高二倍體組初診時白細胞計數明顯高于正常覈型組,而正常覈型組總生存(OS)率較業二倍體和假二倍體組高,無複髮生存(RFS)期較亞二倍體和假二倍體組長.③染色體畸變類型分組比較:Ph暘性組初診時白細胞計數明顯高于Ph陰性組,而OS率較Ph陰性組低,RFS期較Ph陰性組短;單純Ph暘性組與Ph暘性伴附加染色體異常組在臨床特徵、OS率和RFS期間的差異均無統計學意義.同時Ph暘性伴附加染色體異常組的OS期和RFS期也明顯短于Ph陰性組.④覈型分組比較:全部覈型正常組(NN)患者較正常與異常覈型共存組(AN)年齡輕,初診時白細胞計數低,融閤基因錶達以P190為主,髓繫抗原錶達率高,RFS率和OS率高;NN組較全部覈型異常組(AA)初診時白細胞計數低,髓外浸潤重,RFS率和OS率高.而AA與AN組之間各項差異均無統計學意義.⑤雙Ph染色體組融閤基因P190比例低于非雙Ph染色體組,OS期短于非雙Ph染色體組.結論 成人Ph+/bcr-abl+ALL患者染色體改變複雜,假二倍體和高二倍體提示預後不良,雙Ph染色體可能提示預後不良.
목적 분석성인Ph염색체화(혹)bc-abl양성(Ph+/bor-abl+)급성림파세포백혈병(ALL)환자세포유전학개,변적특점,탐토기대예후적영향.방법 회고성분석1996년1월지2007년12월취진병행염색체검행적100례성인Ph+/bcr-abl+ALL.환자적림상자료,총결기염색체기변적류형、분포화빈뢰특점,병진행분조연구,탐토불동조지간적림상특점급예후차이.결과 ①72례검출염색체이상,22례위단순Ph염색체양성혹기변이형,44례Ph양성반부가염색체이상,상견적이상유+Ph、-7、+21、-20、+8、9p-、del(22)등.②염색체수목분조비교:가이배체조화고이배체조초진시백세포계수명현고우정상핵형조,이정상핵형조총생존(OS)솔교업이배체화가이배체조고,무복발생존(RFS)기교아이배체화가이배체조장.③염색체기변류형분조비교:Ph양성조초진시백세포계수명현고우Ph음성조,이OS솔교Ph음성조저,RFS기교Ph음성조단;단순Ph양성조여Ph양성반부가염색체이상조재림상특정、OS솔화RFS기간적차이균무통계학의의.동시Ph양성반부가염색체이상조적OS기화RFS기야명현단우Ph음성조.④핵형분조비교:전부핵형정상조(NN)환자교정상여이상핵형공존조(AN)년령경,초진시백세포계수저,융합기인표체이P190위주,수계항원표체솔고,RFS솔화OS솔고;NN조교전부핵형이상조(AA)초진시백세포계수저,수외침윤중,RFS솔화OS솔고.이AA여AN조지간각항차이균무통계학의의.⑤쌍Ph염색체조융합기인P190비례저우비쌍Ph염색체조,OS기단우비쌍Ph염색체조.결론 성인Ph+/bcr-abl+ALL환자염색체개변복잡,가이배체화고이배체제시예후불량,쌍Ph염색체가능제시예후불량.
Objective To analyze the characteristics of cytogenetic aberration of adults with Philadel- phia chromosome-positive (Ph+) and/or bcr-abl positive (bcr-abl+) acute lymphoblastic leukaemia (ALL), and investigate its influence on patients' outcomes. Method Retrospective analysis of 100 adult Ph+ ALL patients from January 1, 1996 to December 31,2007 was carried out. The type, distribution and frequency of chromosome aberration were summarized, and compared among different subgroups. Results ①ln all cases, 72 had chromosome aberrations, including 22 with sole Ph chromosome, 44 Ph+ with additional abnormali-ties, which included double Ph, monosomy 7, monosomy 20, trisomy 8 trisomy 21,9p deletion and 22 dele-tion. ②Patients with pseudodiploid and hyperdiploid had higher WBC count, and inferior outcome with lower rates of overall survival (OS) and relapse free survival (RFS). ③Ph+ group also had higher WBC counts and inferior outcome with low OS and RFS rates. There was no statistic significance between sole Ph+ group and Ph plus additional aberrations group.④ Patients with both abnormal and normal metaphase (AN) and with solely abnormal metaphase(AA) had higher WBC count, less frequent PI90 occurrence and inferior outcome than those only normal metaphase(NN) group, whereas, there was no difference between AA and AN groups. ⑤ Double Ph chromosome had a lower frequency of P190 and inferior OS than non-double Ph grout). Conclusion Adults with Ph+ ALL have complieated eytogenetic abnormalities, pseudodiploid and hyperdip loid indicate inferior outcome, and double Ph chromosome may be a unfavorable prognostic factor.