CAJ | 학술논문

视网膜母细胞瘤蛋白质结合的锌指蛋白1( RIZ1)是一种甲基转移酶,其功能单位为特征性的PR锌指结构域.RIZ1能够通过PR结构域甲基化组蛋白3上第9位的赖氨酸,导致相应基因转录受抑,具有抑制肿瘤发生的作用.RIZ1在多种人类肿瘤中表达减低或缺失,其表达水平减低与肿瘤发生、进展等密切相关,被定义为一种候选抑癌基因.RIZ1在肿瘤中表达减低机制既涉及细胞遗传学又与表观遗传学改变密切相关.
시망막모세포류단백질결합적자지단백1( RIZ1)시일충갑기전이매,기공능단위위특정성적PR자지결구역.RIZ1능구통과PR결구역갑기화조단백3상제9위적뢰안산,도치상응기인전록수억,구유억제종류발생적작용.RIZ1재다충인류종류중표체감저혹결실,기표체수평감저여종류발생、진전등밀절상관,피정의위일충후선억암기인.RIZ1재종류중표체감저궤제기섭급세포유전학우여표관유전학개변밀절상관.
The retinoblastoma-protein-interacting zinc finger proteinl (RIZ1),a methyltransferase,contains the characteristic PR zinc finger domain.RIZ1 can methylate H3K9 of the histone,acted as a transcription suppression factor of cancers.Increasing numbers of human cancers are reported to hold decreased or absent RIZ1 expression,which is closely related to the progression of cancer.RIZ1 is defined as a candidate anti-oncogene.The mechanisms of the suppression involved in both oncocytogenetics and epigenetic changes.