国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2012年
4期
234-237
,共4页
力学载荷%破骨细胞%凋亡%调节
力學載荷%破骨細胞%凋亡%調節
역학재하%파골세포%조망%조절
Mechanical loading%Osteoclast%Apoptosis%Regulation
破骨细胞是参与骨代谢的基本功能细胞之一.破骨细胞在骨重建过程中主要承担旧骨组织的破坏和吸收,因此,破骨细胞凋亡的微小变化都可能会改变骨重建的进程.调节破骨细胞凋亡的因素有很多,如雌激素、二磷酸盐等生物化学因素,但力学载荷对于破骨细胞生物学活性影响的研究相对较少.综述了力学载荷对破骨细胞生物学活性的影响以及细胞凋亡与破骨细胞凋亡的调节.
破骨細胞是參與骨代謝的基本功能細胞之一.破骨細胞在骨重建過程中主要承擔舊骨組織的破壞和吸收,因此,破骨細胞凋亡的微小變化都可能會改變骨重建的進程.調節破骨細胞凋亡的因素有很多,如雌激素、二燐痠鹽等生物化學因素,但力學載荷對于破骨細胞生物學活性影響的研究相對較少.綜述瞭力學載荷對破骨細胞生物學活性的影響以及細胞凋亡與破骨細胞凋亡的調節.
파골세포시삼여골대사적기본공능세포지일.파골세포재골중건과정중주요승담구골조직적파배화흡수,인차,파골세포조망적미소변화도가능회개변골중건적진정.조절파골세포조망적인소유흔다,여자격소、이린산염등생물화학인소,단역학재하대우파골세포생물학활성영향적연구상대교소.종술료역학재하대파골세포생물학활성적영향이급세포조망여파골세포조망적조절.
Osteoclast is one of the basic function cells involved in bone metabolism during the process of bone remodeling.Osteoclasts are responsible for destruction and absorption of the old bone tissue.Thus,a tiny change of osteoclast apoptosis may change the process of bone remodeling.Osteoclast apoptosis is regulated by many factors including estrogen,bisphosphonates and so on.However,fewer researches on effect of mechanical loading on the biological activity of osteoclasts has been carried out.In this paper,the effect of mechanical loading on the biological activity of osteoclasts and its regulation on apoptosis of cells and osteoclast are reviewed.
