中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2011年
10期
783-785
,共3页
粉防己碱%尘肺%免疫球蛋白类%T淋巴细胞亚群
粉防己堿%塵肺%免疫毬蛋白類%T淋巴細胞亞群
분방기감%진폐%면역구단백류%T림파세포아군
TETRANDRINE%Pneumoconiosis%lmmunoglobulins%T-lymphocyte subsets
目的 观察汉防己甲素治疗尘肺疗效及对免疫功能的影响.方法 71例尘肺患者随机分为治疗组(36例)和对照组(35例),治疗组服用汉防己甲素,对照组服用矽肺宁,观察治疗前后和两组间症状变化及治疗前后免疫功能的变化.结果 与治疗前和对照组比较,治疗组用药后咳嗽、胸痛、气紧积分减少,差异有统计学意义(P＜0.05).治疗组症状改善积分下降百分率为69.35％,对照组为50.00％,两组比较,差异有统计学意义(P＜0.05).治疗组上呼吸道感染发生人数和肺部感染人数分别为13例和2例,发生率分别为36.11％和5.55％.对照组上呼吸道感染发生人数和肺部感染人数分别为22例和4例,发生率分别为57.14％和28.57％.,两组比较,差异有统计学意义(P＜0.05).与治疗前比较,治疗组治疗后CD4明显上升,CD8明显下降,CD4/CD8明显上升,差异有统计学意义(P＜0.05).治疗后,与对照组比较,治疗组CD4明显上升,CD8明显下降,CD4/CD8明显上升,差异有统计学意义(P＜0.05).治疗前后,两组间免疫球蛋白( IgG、IgA、IgM)比较,差异无统计学意义(P＞0.05).结论 汉防己甲素有较好的改善尘肺患者临床症状的效果,对细胞免疫功能有一定的调节作用,其症状改善、上呼吸道感染发生率和肺部感染率的减少,可能与机体细胞免疫功能增强有关.
目的 觀察漢防己甲素治療塵肺療效及對免疫功能的影響.方法 71例塵肺患者隨機分為治療組(36例)和對照組(35例),治療組服用漢防己甲素,對照組服用矽肺寧,觀察治療前後和兩組間癥狀變化及治療前後免疫功能的變化.結果 與治療前和對照組比較,治療組用藥後咳嗽、胸痛、氣緊積分減少,差異有統計學意義(P＜0.05).治療組癥狀改善積分下降百分率為69.35％,對照組為50.00％,兩組比較,差異有統計學意義(P＜0.05).治療組上呼吸道感染髮生人數和肺部感染人數分彆為13例和2例,髮生率分彆為36.11％和5.55％.對照組上呼吸道感染髮生人數和肺部感染人數分彆為22例和4例,髮生率分彆為57.14％和28.57％.,兩組比較,差異有統計學意義(P＜0.05).與治療前比較,治療組治療後CD4明顯上升,CD8明顯下降,CD4/CD8明顯上升,差異有統計學意義(P＜0.05).治療後,與對照組比較,治療組CD4明顯上升,CD8明顯下降,CD4/CD8明顯上升,差異有統計學意義(P＜0.05).治療前後,兩組間免疫毬蛋白( IgG、IgA、IgM)比較,差異無統計學意義(P＞0.05).結論 漢防己甲素有較好的改善塵肺患者臨床癥狀的效果,對細胞免疫功能有一定的調節作用,其癥狀改善、上呼吸道感染髮生率和肺部感染率的減少,可能與機體細胞免疫功能增彊有關.
목적 관찰한방기갑소치료진폐료효급대면역공능적영향.방법 71례진폐환자수궤분위치료조(36례)화대조조(35례),치료조복용한방기갑소,대조조복용석폐저,관찰치료전후화량조간증상변화급치료전후면역공능적변화.결과 여치료전화대조조비교,치료조용약후해수、흉통、기긴적분감소,차이유통계학의의(P＜0.05).치료조증상개선적분하강백분솔위69.35％,대조조위50.00％,량조비교,차이유통계학의의(P＜0.05).치료조상호흡도감염발생인수화폐부감염인수분별위13례화2례,발생솔분별위36.11％화5.55％.대조조상호흡도감염발생인수화폐부감염인수분별위22례화4례,발생솔분별위57.14％화28.57％.,량조비교,차이유통계학의의(P＜0.05).여치료전비교,치료조치료후CD4명현상승,CD8명현하강,CD4/CD8명현상승,차이유통계학의의(P＜0.05).치료후,여대조조비교,치료조CD4명현상승,CD8명현하강,CD4/CD8명현상승,차이유통계학의의(P＜0.05).치료전후,량조간면역구단백( IgG、IgA、IgM)비교,차이무통계학의의(P＞0.05).결론 한방기갑소유교호적개선진폐환자림상증상적효과,대세포면역공능유일정적조절작용,기증상개선、상호흡도감염발생솔화폐부감염솔적감소,가능여궤체세포면역공능증강유관.
Objective To observe the curative effect of HanFangJiaSu on pneumoconiosis.Method 71 patients with silicosis were divided into trial group and control group at random.The treating group (36 patients) was treated 90 days with HanFangJiaSu and The contrl group (35 patients) was treated 90 days with XiFeiNing.The silicosis with cough,chest complaint,dyspnoed and immune modulation were observed before treating and after treating.The effect was compared between the two groups.Result To compared with the group before treatment and the control group,the symptoms score of cough,chest complaint and dyspnoed in treated group was significantly decreased after treatment (P＜0.05).The rate was decreased by 69.35％ in treated group and 50.00％ in controls,which showed the treatment in both groups was effective.The rate in treated group was significantly decreased more than in controls(P＜0.05 ).There were 13 cases with respiratory toact infection and 2 cases with lung infection in treated group of which percentage were 36.11％ and 5.55％,while 22 cases and 4 cases in control group of which percentage were 57.14％ and 28.57％.There was a significant difference between the two groups (P＜0.05).To compared with the group before treatment,the quantity of CD4 in blood was obviously increased,while CD8 was obviously decreased,which showed a significant increase of CD4/CD8 (P＜0.05).To compared with control group,the quantity of CD4 in treated group was obviously increased,while CD8 was obviously decreased,which also showed a significant increase of CD4/CD8 (P＜0.05).There was no significant difference with the concentration of immune globulin (IgG,IgA,IgM) between the groups before and after treatment.
