中华口腔医学杂志
中華口腔醫學雜誌
중화구강의학잡지
Chinese Journal of Stomatology
2011年
2期
70-74
,共5页
危晶晶%常春荣%潘亚萍%俞宁%赵宏
危晶晶%常春榮%潘亞萍%俞寧%趙宏
위정정%상춘영%반아평%유저%조굉
牙周炎%糖尿病,2型%白细胞介素6%血红蛋白A,糖基化
牙週炎%糖尿病,2型%白細胞介素6%血紅蛋白A,糖基化
아주염%당뇨병,2형%백세포개소6%혈홍단백A,당기화
Periodontitis%Diabetes mellitus,type 2%Interleukin-6%Hemoglobin A,glycosylated
目的 观察牙周非手术治疗对2型糖尿病伴慢性牙周炎(chronic periodontitis,CP)患者牙周状况、糖代谢及血清白细胞介素6(IL-6)的影响,探讨其可能的影响机制.方法 选取2型糖尿病伴慢性牙周炎(type 2 diabetes mellitus with chronic periodontitis,DMCP组)和不伴有全身系统性疾病的CP患者(CP组)各55例进行牙周非手术治疗,其中DMCP组中糖化血红蛋白(glycated hemoglobin,HbA1c)＜7.00%的患者为血糖控制较好组(A1组),HbAlc≥7.00%的为血糖控制较差组(A2组).在治疗前及治疗后6周、3个月时分别记录全口探诊深度(probing depth,PD)、附着丧失(attachment loss,AL)、出血指数(beeding index,BI)和菌斑指数(plaque index,PLI),并检测空腹血糖(fasting plasma glucose,FPG)、HbA1c及血清IL-6水平.结果 DMCP组和CP组PD、AL、BI、PLI和血清IL-6水平在治疗后6周及3个月时均显著降低(P＜0.05),其中DMCP组血清IL-6从(3.47±0.33)ng/L(治疗前)显著降至(3.21±0.66)ng/L(治疗后6周),再降至(3.03±0.54)ng/L(治疗后3个月).DMCP组治疗后3个月HbA1c水平[(6.80±1.21)%]与治疗前[(7.35±1.73)%]相比显著降低(P＜0.05),其中A2组HbA1c水平从治疗前的(8.72±1.51)%显著降至治疗后3个月的(7.59±1.28)%(P＜0.05),而A1组HbA1c水平则无明显变化(P＞0.05).结论 牙周非手术治疗能够降低DMCP患者血清IL-6水平,并在一定程度上改善患者糖代谢状况;该治疗能显著改善血糖控制较差者的糖代谢,而对血糖控制较好者的糖代谢则无明显影响.
目的 觀察牙週非手術治療對2型糖尿病伴慢性牙週炎(chronic periodontitis,CP)患者牙週狀況、糖代謝及血清白細胞介素6(IL-6)的影響,探討其可能的影響機製.方法 選取2型糖尿病伴慢性牙週炎(type 2 diabetes mellitus with chronic periodontitis,DMCP組)和不伴有全身繫統性疾病的CP患者(CP組)各55例進行牙週非手術治療,其中DMCP組中糖化血紅蛋白(glycated hemoglobin,HbA1c)＜7.00%的患者為血糖控製較好組(A1組),HbAlc≥7.00%的為血糖控製較差組(A2組).在治療前及治療後6週、3箇月時分彆記錄全口探診深度(probing depth,PD)、附著喪失(attachment loss,AL)、齣血指數(beeding index,BI)和菌斑指數(plaque index,PLI),併檢測空腹血糖(fasting plasma glucose,FPG)、HbA1c及血清IL-6水平.結果 DMCP組和CP組PD、AL、BI、PLI和血清IL-6水平在治療後6週及3箇月時均顯著降低(P＜0.05),其中DMCP組血清IL-6從(3.47±0.33)ng/L(治療前)顯著降至(3.21±0.66)ng/L(治療後6週),再降至(3.03±0.54)ng/L(治療後3箇月).DMCP組治療後3箇月HbA1c水平[(6.80±1.21)%]與治療前[(7.35±1.73)%]相比顯著降低(P＜0.05),其中A2組HbA1c水平從治療前的(8.72±1.51)%顯著降至治療後3箇月的(7.59±1.28)%(P＜0.05),而A1組HbA1c水平則無明顯變化(P＞0.05).結論 牙週非手術治療能夠降低DMCP患者血清IL-6水平,併在一定程度上改善患者糖代謝狀況;該治療能顯著改善血糖控製較差者的糖代謝,而對血糖控製較好者的糖代謝則無明顯影響.
목적 관찰아주비수술치료대2형당뇨병반만성아주염(chronic periodontitis,CP)환자아주상황、당대사급혈청백세포개소6(IL-6)적영향,탐토기가능적영향궤제.방법 선취2형당뇨병반만성아주염(type 2 diabetes mellitus with chronic periodontitis,DMCP조)화불반유전신계통성질병적CP환자(CP조)각55례진행아주비수술치료,기중DMCP조중당화혈홍단백(glycated hemoglobin,HbA1c)＜7.00%적환자위혈당공제교호조(A1조),HbAlc≥7.00%적위혈당공제교차조(A2조).재치료전급치료후6주、3개월시분별기록전구탐진심도(probing depth,PD)、부착상실(attachment loss,AL)、출혈지수(beeding index,BI)화균반지수(plaque index,PLI),병검측공복혈당(fasting plasma glucose,FPG)、HbA1c급혈청IL-6수평.결과 DMCP조화CP조PD、AL、BI、PLI화혈청IL-6수평재치료후6주급3개월시균현저강저(P＜0.05),기중DMCP조혈청IL-6종(3.47±0.33)ng/L(치료전)현저강지(3.21±0.66)ng/L(치료후6주),재강지(3.03±0.54)ng/L(치료후3개월).DMCP조치료후3개월HbA1c수평[(6.80±1.21)%]여치료전[(7.35±1.73)%]상비현저강저(P＜0.05),기중A2조HbA1c수평종치료전적(8.72±1.51)%현저강지치료후3개월적(7.59±1.28)%(P＜0.05),이A1조HbA1c수평칙무명현변화(P＞0.05).결론 아주비수술치료능구강저DMCP환자혈청IL-6수평,병재일정정도상개선환자당대사상황;해치료능현저개선혈당공제교차자적당대사,이대혈당공제교호자적당대사칙무명현영향.
Objective To evaluate the effect of non-surgical periodontal therapy on periodontal status, glycemic control and the level of serum interleukin(IL)-6 in type 2 diabetic patients with chronic periodontitis (DMCP). Methods Fifty-five DMCP and 55 systemically healthy patients with chronic periodontitis(CP) were recruited in this study. The diabetes were classified into two groups, the wellcontrolled group [glycated hemoglobin (HbA1c) ＜ 7.00%]and the poorly controlled group (HbA1c ≥7.00%). All subjects received non-surgical periodontal therapy. Periodontal clinical parameters including periodontal probing depth (PD), attachment loss (AL), bleeding index (BI) and plaque index (PLI) were recorded at baseline, 6 weeks and 3 months after the treatment. Fasting plasma glucose(FPG), HbA1c and the concentration of serum IL-6 were measured. Results At 6 weeks and 3 months after treatment, PD,AL, BI, PLI and the concentration of serum IL-6 of both groups significantly reduced(P ＜ 0. 05). The level of IL-6 in diabetic patients reduced significantly from (3.47 ±0.33) ng/L to (3.21 ±0.66) ng/L and to (3.03 ± 0. 54) ng/L. The HbA1c of diabetic patients reduced significantly 3 months after treatment [(6.80±1.21%]compared with the baseline[(7.35 ± 1.73)%, P ＜0.05]. HbA1c of the poorly controlled group reduced significantly(P ＜0. 05), while HbA1c of the well-controlled diabetes did not show any apparent reduction (P ＞ 0. 05). Conclusions Non-surgical periodontal therapy can effectively reduce the concentration of serum IL-6, thereby improving glycemic control in type 2 diabetes patients with chronic periodontitis. However, there was no any significant reduction of HbA1c in the well-controlled diabetes.
