CAJ | 학술논문

研究复方地塞米松磷酸钠凝胶的最佳处方及柠檬桉叶油对地塞米松磷酸钠透皮扩散作用的影响.用正交试验法对复方地塞米松凝胶制的处方进行优化;用离体家兔皮肤作为试验材料,采用药物透皮仪对凝胶中地塞米松进行透皮扩散试验,紫外分光光度法测定地塞米松透皮扩散的累积渗透量,配对t检验法验证柠檬桉叶油对地塞米松磷酸钠是否有促透作用.复方地塞米松磷酸钠凝胶的最佳处方是：地塞米松磷酸钠占1.5%,卡波姆-940占2%,柠檬桉叶油占6%,丙三醇占4%,乙醇占6%,尼泊金乙脂和三乙醇胺适量.柠檬桉叶油提高凝胶中地塞米松磷酸钠的皮肤累积渗透量和稳态渗透流量均有显著性的意义（P〈0.05）.柠檬桉叶油对地塞米松磷酸钠有透皮促进作用.
연구복방지새미송린산납응효적최가처방급저몽안협유대지새미송린산납투피확산작용적영향.용정교시험법대복방지새미송응효제적처방진행우화;용리체가토피부작위시험재료,채용약물투피의대응효중지새미송진행투피확산시험,자외분광광도법측정지새미송투피확산적루적삼투량,배대t검험법험증저몽안협유대지새미송린산납시부유촉투작용.복방지새미송린산납응효적최가처방시：지새미송린산납점1.5%,잡파모-940점2%,저몽안협유점6%,병삼순점4%,을순점6%,니박금을지화삼을순알괄량.저몽안협유제고응효중지새미송린산납적피부루적삼투량화은태삼투류량균유현저성적의의（P〈0.05）.저몽안협유대지새미송린산납유투피촉진작용.
To research the best prescription of compound dexamethasone sodium phosphate jelly and the effect of citriodora oil on the transdermal delivery of dexamethasone sodium phosphate.With the cross test the best prescription of dexamethasone sodium phosphate jelly was found out.The transdermal delivery of dexamethasone sodium phosphate in the jelly was determined utilizing modified diffusion cells in rabbit skin in vitro.The accumulation permeation amounts of dexamethasone sodium phosphate were determined with ultraviolet spectrophotometer.With the pair of t test the effect of citriodora oil on the transdermal delivery of dexamethasone sodium phosphate was tested.The best prescription of compound dexamethasone sodium phosphate jelly was 1.5% of dexamethasone sodium phosphate,2% of carbomer-940,6% citriodora oil,4% glycerol,6% ethanol and the right amount of ethylparaben and triethanolamine.The enhancement effects of citriodora oil on the accumulation permeation and permeation rate of dexamethasone sodium phosphate in the jelly were significant（P0.05）.Citriodora oil could enhance the transdermal delivery of dexamethasone sodium phosphate.