CAJ | 학술논문

目的探讨大鼠减体积肝移植术后早期死亡的原因.方法选择170对健康SD大鼠,体质量为260～280 g,供体为雌性(170只),受体为雄性(170只),供、受体体质量相差10 g,一般为供体体质量比受体体质量轻.改良前术式实施70只,改良后术式实施100只.结果成功实施的170只大鼠减体积肝移植模型中,早期(术后12 h～术后3 d)死亡25只,早期死亡率为14.7%,其中改良前术式死亡18只,改良后术式死亡7只.早期死亡的原因分布为:腹腔出血8只(4.7%),肠梗阻4只(2.4%),气体栓塞3只(1.8%),肝功能不良3只(1.8%),气胸3只(1.8%),肺部感染2只(1.2%),复温过度2只(1.2%).结论大鼠减体积肝移植术后早期最常见的死亡原因是腹腔出血,其次为肝功能不良、气体栓塞、肠梗阻、气胸、肺部感染和复温过度.
목적 탐토대서감체적간이식술후조기사망적원인.방법 선택170대건강SD대서,체질량위260～280 g,공체위자성(170지),수체위웅성(170지),공、수체체질량상차10 g,일반위공체체질량비수체체질량경.개량전술식실시70지,개량후술식실시100지.결과 성공실시적170지대서감체적간이식모형중,조기(술후12 h～술후3 d)사망25지,조기사망솔위14.7%,기중개량전술식사망18지,개량후술식사망7지.조기사망적원인분포위:복강출혈8지(4.7%),장경조4지(2.4%),기체전새3지(1.8%),간공능불량3지(1.8%),기흉3지(1.8%),폐부감염2지(1.2%),복온과도2지(1.2%).결론 대서감체적간이식술후조기최상견적사망원인시복강출혈,기차위간공능불량、기체전새、장경조、기흉、폐부감염화복온과도.
Objective To analyze the cause of early death after reduce-size liver transplantationin rats.Methods One hundred seventy healthy SD rats (260～280 g body weight) were enrolled The donors were female (n=170),the receptors male (n=170),the body weight difference between them was 10 g,generally donors lighter than receptors.Seventy received unimproved operation,and 100 received improved.Results Twenty-five of 170 rats having received reduced-size liver transplantation successfully died early (including 18 rats having received unimproved operation,7 received improved,12 h～3 d after operation,),with an early mortality of 14.7%.Early death causes were intra-abdominal bleeding (4.7%),intestinal obstruction (2.4%),gas embolism (1.8%),liver dysfunction (1.8%),pneumothorax (1.8%),pulmonary infection (1.2%) and excessive rewarming (1.2%).Conclusion The commonest early death cause of rat reduced-size liver transplantation is intra-abdominal bleeding,followed by liver dysfunction,gas embolism,intestinal obstruction,pneumothorax,pulmonary infection and excessive rewarming.