CAJ | 학술논문

以三聚磷酸钠为交联剂,采用离子交联法制备了氟苯尼考/壳聚糖纳米微球,用激光粒度分析仪、扫描电镜表征了该纳米微球的微观结构和形态,并通过Zeta电位和红外光谱分析该载药纳米微球的形成机理.结果显示:当氟苯尼考与壳聚糖的质量分数为3∶5、壳聚糖与三聚磷酸钠的质量分数为5∶1时,氟苯尼考/壳聚糖纳米微球对氟苯尼考有较大的包封率(64.5%)和载药量(44.0%),并具有较好的缓释性能(45.5 h内释放79.2%),作为氟苯尼考的缓释剂型是可行的.药物释放曲线符合一级动力学方程.
이삼취린산납위교련제,채용리자교련법제비료불분니고/각취당납미미구,용격광립도분석의、소묘전경표정료해납미미구적미관결구화형태,병통과Zeta전위화홍외광보분석해재약납미미구적형성궤리.결과현시:당불분니고여각취당적질량분수위3∶5、각취당여삼취린산납적질량분수위5∶1시,불분니고/각취당납미미구대불분니고유교대적포봉솔(64.5%)화재약량(44.0%),병구유교호적완석성능(45.5 h내석방79.2%),작위불분니고적완석제형시가행적.약물석방곡선부합일급동역학방정.
Florfenicol(FF)/Chitosan(CS) drug-loaded nanospheres (FF-CM) was prepared by ionic crosslinking method with tripolyphosphate (TPP) as crosslinker. A study on these nanospheres' microstructures and configurations was conducted through observation of laser particle size analyzer, fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The results indicated that FF/CS drug-loaded nanospheres had a higher encapsulation rate (64.5%) and loading-drug rate (44.0%) when the mass ratio of FF to CS was 3∶5 and that of CS to TPP was 5∶1 and lower release rate (79.2% released in 45.5 h), so it is feasible for FF/CS drug-loaded nanospheres to be used as a sustained release form of florfenicol. The release curve of FF/CS drug-loaded nanospheres showed that the release processes of florfenicol followed a first-order kinetic model.