CAJ | 학술논문

目的探讨血液灌流联合血液透析对尿毒症周围神经病变的疗效和机制.方法将36例尿毒症周围神经病变的血液透析患者随机分为血液灌/血液透析组(HP-HD)和常规血液透析组(HD).HP-HD组在每周2次常规血液透析的同时,接受每周1次HP-HD治疗;常规血液透析组(HD)行每周3次常规HD治疗.观察、记录治疗前、治疗2个月后两组患者周围神经病变的临床症状、血PTH浓度和正中神经、胫神经、腓总神经的感觉神经传导速度(SCV).结果经过2个月的治疗后,HD组患者周围神经病变的临床症状、血PTH、感觉神经传导速度无明显改善,而HP-HD组患者周围神经病变的临床症状、血PTH及感觉神经传导速度(SCV)均较治疗前有明显改善,其程度显著优于HD组(P<0.05).结论血液灌流联合血液透析对尿毒症周围神经病变疗效确切.
목적 탐토혈액관류연합혈액투석대뇨독증주위신경병변적료효화궤제.방법 장36례뇨독증주위신경병변적혈액투석환자수궤분위혈액관/혈액투석조(HP-HD)화상규혈액투석조(HD).HP-HD조재매주2차상규혈액투석적동시,접수매주1차HP-HD치료;상규혈액투석조(HD)행매주3차상규HD치료.관찰、기록치료전、치료2개월후량조환자주위신경병변적림상증상、혈PTH농도화정중신경、경신경、비총신경적감각신경전도속도(SCV).결과 경과2개월적치료후,HD조환자주위신경병변적림상증상、혈PTH、감각신경전도속도무명현개선,이HP-HD조환자주위신경병변적림상증상、혈PTH급감각신경전도속도(SCV)균교치료전유명현개선,기정도현저우우HD조(P<0.05).결론 혈액관류연합혈액투석대뇨독증주위신경병변료효학절.
Objective To observe the efficacy and mechanism of the hemoperfusion-hemodialysis in treating uremic per-pheral neuropathy. Methods Thirty-six patients with uremic peripheral neuropathy were assigned randomly to hemoperfusion-hemodialysis group,hemodialysis group. Patients of hemoperfusion-hemodialysis group received regular hemodialysis twice a week and hemoparfusion-hemodialysis once a week. The hemodialysis group received regular hemodialysis thrice a week. The clinical symptoms, PTH, the nerve reflex and the sensory conduction velocity(scv) of median nerve, tibial nerve and lateral popliteal nerve were observed in each group before,and 2 months cost treatment respectively. Results After treatment, the clinical symptoms, PTH, the nerve reflex and the scv showed no improvement in the hemodialysis group, but significantly improvement in the he-moperfusion-hemodialysis group(P<0.05). Conclusion Hemodiafiltration are effective for patients with uremic peripheral heuropathy.