CAJ | 학술논문

背景:纳米羟基磷灰石因其与天然骨中的盐类成分一致,与骨中羟基磷灰石的尺寸接近,因而成为骨修复材料的较好选择.设计、时间及地点:材料学动物实验观察,2003-01/2005-06于佳木斯大学实验动物中心及北京积水潭医院完成.目的:探讨纳米羟基磷灰石修复颌骨缺损的可行性.材料:采用磷酸二氢钙和氢氧化钙中和反应构造体系,通过控制反应条件,适量加入形核剂,使反应物成为胶体状态,在不同反应条件下得到针状羟基磷灰石纳米晶体,再进行烧结除处理,得到羟基磷灰石纳米粒子,直径为1～56 nm.方法:24只大耳白兔于颌下区各皮,麻醉后在下颌骨体部以GX微型钻机慢速制作一面积为1.5cm×1.5cm的骨缺损.将24只大耳白兔随机分实验组和对照组,12只/组.实验组采用纳米羟基磷灰石修复,对照组采用普通羟基磷灰石修复,并应用抗生素5 d.主要观察指标:纳米羟基磷灰石植入骨缺损后骨密度的变化.结果:骨缺损修复后,实验组骨密度随时间的延长逐渐增大,直至与正常的骨密度接近并趋于稳定;对照组骨密度随时间的延长逐渐减小.实验组与对照组比较,差异有显著意义(P<0.01).结论:纳米羟基磷灰石修复骨缺损,骨成熟较快,是修复骨缺损的良好材料.
배경:납미간기린회석인기여천연골중적염류성분일치,여골중간기린회석적척촌접근,인이성위골수복재료적교호선택.설계、시간급지점:재료학동물실험관찰,2003-01/2005-06우가목사대학실험동물중심급북경적수담의원완성.목적:탐토납미간기린회석수복합골결손적가행성.재료:채용린산이경개화경양화개중화반응구조체계,통과공제반응조건,괄량가입형핵제,사반응물성위효체상태,재불동반응조건하득도침상간기린회석납미정체,재진행소결제처리,득도간기린회석납미입자,직경위1～56 nm.방법:24지대이백토우합하구각피,마취후재하합골체부이GX미형찬궤만속제작일면적위1.5cm×1.5cm적골결손.장24지대이백토수궤분실험조화대조조,12지/조.실험조채용납미간기린회석수복,대조조채용보통간기린회석수복,병응용항생소5 d.주요관찰지표:납미간기린회석식입골결손후골밀도적변화.결과:골결손수복후,실험조골밀도수시간적연장축점증대,직지여정상적골밀도접근병추우은정;대조조골밀도수시간적연장축점감소.실험조여대조조비교,차이유현저의의(P<0.01).결론:납미간기린회석수복골결손,골성숙교쾌,시수복골결손적량호재료.
BACKGROUND: Nano-hydroxyapatite (Nano-HA) has been shown to be a good choice of bone repair material owing to its salts composition consistent with natural bone and its scaffold structure homothetic to natural bone structure. OBJECTIVE: To investigate the feasibility of nano-HA in repair of jaw bone defect in rabbits. DESIGN, TIME AND SETTING: Materials-based animal experimental observation was performed at Laboratory Animal Center of Jiamusi University and Beijing Ji Shui Tan Hospital between January 2003 and June 2005. MATERIALS: Neutralization reaction of calcium biphosphate and calcium hydroxide was used to construct the system. The reactants were managed to be cotloidal by reaction control and using appropriate nucleating agents. Acerata HA crystal obtained under different conditions was sintered to obtain the nano-HA granule with a diameter of 1-56 nm. METHODS: Twenty-four healthy Chinese Harbin rabbits were randomly and evenly divided into an experimental group and a control group. After anesthesia, a penetrating 1.5 cm x1.5 cm defect was made with the GX micro-drill at the mandibular edge in each rabbit. Nano-HA was implanted in defects of the experimental group, and common HA was used in the control group. Antibiotics were used for 5 days afterwards. MAIN OUTCOME MEASURES: Change in bone mineral density after implantation of nano-HA. RESULTS: After repair of bone defect, the bone mineral density in the expedmental group increased gradually to a normal level and tended to be stable; whereas it was gradually decreased in the control group. There was significant difference between the experimental and control groups (P < 0.01). CONCLUSION: Nano-HA can promote new bone maturation, and this material produces favorable results in repair of bone defects.