CAJ | 학술논문

目的对比研究复合环孢菌素同种异体骨(CAB)与冻干同种异体骨(FDAB)修复兔桡骨缺损效果.方法 30只新西兰大白兔,随机分为材料提供组、实验组、对照组3组,每组10只.取材料提供组双侧髂骨制备CAB及FDAB.制备兔右侧桡骨中段10 mm的骨与骨膜缺损,实验组植入CAB修复,对照组植入FDAB修复.术后4、12周每组各处死5只动物,进行大体标本、X线片和组织学观察.结果术后4周,实验组X线片评分高于对照组(P=0 .001),缺损区新骨形成量及异体骨与受体骨融合性均高于对照组;术后12周,实验组X线片评分高于对照组(P=0.001),缺损区骨塑形效果优于对照组.结论CAB修复兔桡骨缺损效果优于FDAB,是否为局部免疫反应状态的不同造成这种差异需进一步探讨.
목적 대비연구복합배포균소동충이체골(CAB)여동간동충이체골(FDAB)수복토뇨골결손효과.방법 30지신 서란대백토,수궤분위재료제공조、실험조、대조조3조,매조10지.취재료제공조쌍측가골제비CAB급FDAB.제비토우측뇨골중단10 mm적골여골막결손,실험조식입CAB수복,대조조식입FDAB수복.술후4、12주매조각처사5지동물,진행대체표본、X선편화조직학관찰.결과 술후4주,실험조X선편평분고우대조조(P=0 .001),결손구신골형성량급이체골여수체골융합성균고우대조조;술후12주,실험조X선편평분고우대조조(P=0.001),결손구골소형효과우우대조조.결론CAB수복토뇨골결손효과우우FDAB,시부위국부면역반응상태적불동조성저충차이수진일보탐토.
Objective To compare the effects of cyclosporine-impregnated bone allograft (CAB) and freeze-dried bone allograft (FDAB) in repairing radial defects in rabbits. Methods Thirty New Zealand white rabbits were randomized into bone graft donor group, experimental group, and control group (n=10). The bilateral ilia of the donor rabbits were dissected to prepare CAB and FDAB. In the other 20 rabbits, a 10-mm long segmental osteoperiosteal defect was induced in the right radius and repaired with CAB (experimental group) or with FDAB (control group). At postoperative weeks 4 and 12, 5 rabbits from each group were sacrificed to evaluate the bone healing by radiographic, general and histological observations. Results Four weeks after the operation, the rabbits in the experimental group showed significantly higher X-ray scores (P=0.001) with greater amount of new bone and better incorporation of the allograft and autogenous bone than those in the control group. At.12 weeks, the X-my scores were still significantly higher in the experimental group (P=0.002), which also showed better bone remodeling than the control group. Conclusion CAB is superior to FDAB for repairing radial defects in rabbits, but the potential involvement of local immunoreaetion in this difference awaits further investigation.