CAJ | 학술논문

[目的]研究广东揭阳地区食管癌高发现场患者的抑癌基因Rb蛋白表达的情况及其意义。[方法]利用免疫组化SP法对揭阳地区60例食管癌标本进行Rb蛋白的检测。[结果]60例食管癌中，Rb蛋白表达总阳性率为56.7％(34／60)，有淋巴结转移组癌组织中的Rb蛋白表达阳性率为70％(14／20)，无淋巴结转移组阳性率为50％(20／40)，两组表达率之间的差异有显著性意义。中分化组癌细胞的Rb阳性表达率为39.4％(13／33)，低分化组的阳性表达率为76.0％，Rb蛋白在高低分化程度的食管癌之间的表达率有显著性差异(P=0.006)。[结论]Rb蛋白的异常表达与食管癌的分化程度有关，而与淋巴结转移无相关性。检测食管癌患者Rb基因表达对于综合判断患者的预后，指导临床治疗有一定的价值和意义。
[목적]연구엄동게양지구식관암고발현장환자적억암기인Rb단백표체적정황급기의의。[방법]이용면역조화SP법대게양지구60례식관암표본진행Rb단백적검측。[결과]60례식관암중，Rb단백표체총양성솔위56.7％(34／60)，유림파결전이조암조직중적Rb단백표체양성솔위70％(14／20)，무림파결전이조양성솔위50％(20／40)，량조표체솔지간적차이유현저성의의。중분화조암세포적Rb양성표체솔위39.4％(13／33)，저분화조적양성표체솔위76.0％，Rb단백재고저분화정도적식관암지간적표체솔유현저성차이(P=0.006)。[결론]Rb단백적이상표체여식관암적분화정도유관，이여림파결전이무상관성。검측식관암환자Rb기인표체대우종합판단환자적예후，지도림상치료유일정적개치화의의。
[Purpose] To explore the expression of Rb tumor suppressor gene in the esophageal carcinoma from a high-incidence area,Jieyang, Guangdong province, and to investigate its clinic significance. [ Methods] Paraffin - embedded specimens of 60 cases were examined immunohistochemically. [Results] In the 60 cases with esophageal carcinoma overall Rb protein expression rate was 56.7%(34/60). There was no significant difference between positive node group and negative node group, with the expression rate of 70% (14/20) and 50% (20/40) re spectively. There was significant difference between moderate and poor differentiation, with the expression rate of 39.4% (13/33) and 76.0% (19/25) respectively. [Conclusion] Rb protein expression is significantly correlated with the differentiation of esophageal carcinoma,but not with lymph node metastasis. It plays certain role in the treatment and predicating prognosis for the patients with esophageal carcinoma.