CAJ | 학술논문

目的观察比较异丙酚和哌替啶、氟哌啶辅助上腹部手术的临床效果。方法选择46例ASAⅠ－Ⅱ级行上腹部手术患者，随机分为异丙酚组（Ⅰ组）与哌、氟组（Ⅱ组），每组23例。硬膜外阻滞选T8－10，阻滞平面控制在T3－4阻滞平面稳定后，Ⅰ组静注负荷量异丙酚0.75mg/kg，5min后微泵持续输注2mg·kg－1·h－1，Ⅱ组静注哌替啶50mg，氟哌啶2.5mg。观察记录注药前后各时点参数值及不良反应、术中感受。结果Ⅰ组注药后5minSpO2明显下降（p<0.05），Ⅱ组注药后10min，20minSpO2明显下降（p<0.05）。VAS评分Ⅰ组（90％）明显高于Ⅱ组（30％）（p<0.05）。Ⅰ组不良反应发生率明显降低。结论异丙酚辅助硬膜外神经阻滞行上腹部手术安全可行，优于哌、氟合剂。
목적관찰비교이병분화고체정、불고정보조상복부수술적림상효과。방법선택46례ASAⅠ－Ⅱ급행상복부수술환자，수궤분위이병분조（Ⅰ조）여고、불조（Ⅱ조），매조23례。경막외조체선T8－10，조체평면공제재T3－4조체평면은정후，Ⅰ조정주부하량이병분0.75mg/kg，5min후미빙지속수주2mg·kg－1·h－1，Ⅱ조정주고체정50mg，불고정2.5mg。관찰기록주약전후각시점삼수치급불량반응、술중감수。결과Ⅰ조주약후5minSpO2명현하강（p<0.05），Ⅱ조주약후10min，20minSpO2명현하강（p<0.05）。VAS평분Ⅰ조（90％）명현고우Ⅱ조（30％）（p<0.05）。Ⅰ조불량반응발생솔명현강저。결론이병분보조경막외신경조체행상복부수술안전가행，우우고、불합제。
Objective To observe the effect of propofol as an adjuvant during epidural blockade in upper abdominal surgery. Methods 46 ASA Ⅰ ～ Ⅱ patients undergoing upper abdominal surgery were allocated randomly into group Ⅰ (propofol group) or group Ⅱ (50mg pethidine and 2.5mg droperidol). Results A significant decrease of SpO2 was observed 5 min after a bolus of propofol in group Ⅰ and 10～ 20 min after pethidine and droperidol were given in group Ⅱ . The VAS>7― 8 reached 90％ in group Ⅰ , but only 30％ in group Ⅱ . Conclusion As an adjuvant of epidural blockade, propofol was safe and better than pethidine and droperidol mixture.