CAJ | 학술논문

目的：了解温阳健心灵口服液 (WYJXLD)对收缩功能不全性心力衰竭(心衰)的疗效。方法：120例患者随机分2组，实验组给予WYJXLD、对照组给予开搏通治疗，疗程均为2周。治疗前后均做多普勒超声心功能检查，部分患者做心钠素（ANF）、内皮素（ET ）和甲状腺激素（FT3、FT4）测定。治疗后按卫生部颁布的《中药新药治疗充血性心衰指导原则》进行疗效判定。结果：实验组总有效率67.8％，对照组60.0％，2组疗效经Ridit分析无显著差异。实验组治疗后心脏收缩功能指标〔如射血分数（EF）和左心室后壁增厚率（ΔT％）〕明显增加（P<0.01）；另外，对伴舒张功能不全者，其A ／E比值和A峰也明显下降（P<0.05）。上述心功能指标的改善均优于对照组（P均 <0 .05）。实验组心脏舒张功能的改善似从属于收缩功能的改善。在改善心功能的同时，实验组ANF 和FT3也明显升高(P<0.05)。FT3的提高和心功能改善明显相关，而FT4的提高和心功能改善的关系不大。结论：WYJXLD对收缩功能不全性心衰有良好的近期疗效。
목적：료해온양건심령구복액 (WYJXLD)대수축공능불전성심력쇠갈(심쇠)적료효。방법：120례환자수궤분2조，실험조급여WYJXLD、대조조급여개박통치료 ，료 정균위2주。치료전후균주다보륵초성심공능검사，부분환자주심납소（ANF）、내피소（ET ）화갑상선격소（FT3、FT4）측정。치료후안위생부반포적《중약신약치료충혈성심쇠 지 도원칙》진행료효판정。결과：실험조총유효솔67.8％，대조조60.0％，2조료효경Ridit분석무현저차이。실험조치료후심장수축공능지표〔여사혈분수（EF）화 좌심실후벽증후솔（ΔT％）〕명현증가（P<0.01）；령외，대반서장공능불전자， 기A ／E비치화A봉야명현하강（P<0.05）。상술심공능지표적개선균우우대조조（P균 <0 .05）。실험조심장서장공능적개선사종속우수축공능적개선。재개선심공능적동시，실험 조ANF 화FT3야명현승고(P<0.05)。FT3적제고화심공능개선명현상관，이FT4적제고 화심공능개선적관계불대。결론：WYJXLD대수축공능불전성심쇠유량호적 근기료효。
Objective:To study the curative effect of Wenyang Jianxin Ling drink(WYJXLD,温阳健心灵口服液) on deficient systolic heart failure.Methods:One hundred and twenty patients were randomly divided into two groups,they were given WYJXLD(trial group) or captopril(control group) respectively for 2 weeks.The cardiac function was evaluated by Doppler echocardi ography in all pa tients and the levels of atrial natriuretic factor(ANF),endoth elin(ET) and free triiodothyronine(FT3)，free thyroxine(FT4) before and afte r t reatment were measured in partial patients separately.The curative effect was j udged by the 《Guideprinciple of Traditional Chinese Medicine Treati ng Congestive Heart Failure》 published by the Public Health Department.Results:Two groups had no difference in effective rate by Radit analyse (67.8% vs.60. 0%).The indexes about systolic function such as ejection fraction(EF) and the t h ickening rate of left ventricular posterior wall were significantly increased in trial group(P<0.01).The A/E ratio and peak Awave were decr eased obviously in cases who had diastolic heart failure simultaneously in trial group (P<0.05).The improvement of abovementioned cardiac function indexes in trial group were superior to those in control group (P< 0.05).The improvement of the diastolic function seemed to subordinate to the improveme nt of systolic function. With the improvements of cardiac functions the ANF, FT ３ and FT４ were obviously increased in trial group.Regarding the thyroid h ormone the increase in FT３ was markedly related to the improvement of cardiac function but the increase in FT４ was not.Conclusions:WYJXLD has good shortterm curative effect on systolic heart failure in the near future.