CAJ | 학술논문

目的探讨高脂血症家族遗传因素与心血管病危险因素个体聚集性的关系。方法采用遗传流行病学研究方法，分析高脂血症先证者一级亲属与二级亲属心血管病危险因素的个体聚集性。其中，家族性混合型高脂血症家系15个（共93人），家族性高胆固醇血症家系11个（共94人）。结果超重、高收缩压、高舒张压、高apoB血症、高血糖、低水平高密度脂蛋白胆固醇，这6种高危因素中，心血管病危险因素的个体聚集性随着先证者亲属亲缘系数的下降而下降（P<0.01）。结论高脂血症家族遗传因素对心血管病危险因素的聚集起着重要作用。
목적 탐토고지혈증가족유전인소여심혈관병위험인소개체취집성적관계。방법 채용유전류행병학연구방법，분석고지혈증선증자일급친속여이급친속심혈관병위험인소적개체취집성。기중，가족성혼합형고지혈증가계15개（공93인），가족성고담고순혈증가계11개（공94인）。결과 초중、고수축압、고서장압、고apoB혈증、고혈당、저수평고밀도지단백담고순，저6충고위인소중，심혈관병위험인소적개체취집성수착선증자친속친연계수적하강이하강（P<0.01）。결론 고지혈증가족유전인소대심혈관병위험인소적취집기착중요작용。
Objective To explore the relationship between genetic factors of hyperlipidemia and the clustering of cardiovascular risk factors. Methods Twenty-six pedigrees including familial combined hyperlipidemia (15 families) with 93 members and familial hypercholesterolemia (11 families) with 94 members were recruited from Beijing suburb. To analysis the difference of clustering of cardiovascular risk factors between first relative and second relative by adopting genetic epidemiology methods. Results Among six risk factors including overweight, high SBP, high DBP, high level of apolipoproteinB(apoB), high blood glucose and low high density lipoprotein cholesterol (HDLc), the decreasing of the risk factors clustering was significant correlated with the decline of relationship coefficiency(P<0.01). Conclusion The underlying genetic factors of hyperlipidemia play an important role in the clustering of cardiovascular risk factors.