安徽中医学院学报
安徽中醫學院學報
안휘중의학원학보
2001年
1期
43-44
,共2页
绞股蓝总皂苷%Lewis肺癌%免疫功能
絞股藍總皂苷%Lewis肺癌%免疫功能
교고람총조감%Lewis폐암%면역공능
Gypenosides%Lewis lung cancer%Immunological function
目的：研究绞股蓝总皂苷(gypenosides,GPs)对小鼠Lewis肺癌肿瘤生长、脾淋巴细胞数及NK细胞活性的影响。方法：采用整体动物的抑瘤试验、脾淋巴细胞计数及NK细胞活性测定。结果：GPs对小鼠Lewis肺癌细胞具有明显的抑制作用，在剂量10、20、40mg/kg腹腔注射(ip)给药条件下，其瘤重抑制率(TWI)分别为(29.8±1.3)%、(51.4±2.2)%和(50.0±1.6)%。同时，GPs ip给药后荷瘤小鼠脾淋巴细胞总数明显增加，外周血NK细胞活性明显升高，脾NK细胞活性也明显升高。结论：GPs的抗肿瘤作用与其对荷瘤小鼠免疫功能的增强作用密切相关。
目的：研究絞股藍總皂苷(gypenosides,GPs)對小鼠Lewis肺癌腫瘤生長、脾淋巴細胞數及NK細胞活性的影響。方法：採用整體動物的抑瘤試驗、脾淋巴細胞計數及NK細胞活性測定。結果：GPs對小鼠Lewis肺癌細胞具有明顯的抑製作用，在劑量10、20、40mg/kg腹腔註射(ip)給藥條件下，其瘤重抑製率(TWI)分彆為(29.8±1.3)%、(51.4±2.2)%和(50.0±1.6)%。同時，GPs ip給藥後荷瘤小鼠脾淋巴細胞總數明顯增加，外週血NK細胞活性明顯升高，脾NK細胞活性也明顯升高。結論：GPs的抗腫瘤作用與其對荷瘤小鼠免疫功能的增彊作用密切相關。
목적：연구교고람총조감(gypenosides,GPs)대소서Lewis폐암종류생장、비림파세포수급NK세포활성적영향。방법：채용정체동물적억류시험、비림파세포계수급NK세포활성측정。결과：GPs대소서Lewis폐암세포구유명현적억제작용，재제량10、20、40mg/kg복강주사(ip)급약조건하，기류중억제솔(TWI)분별위(29.8±1.3)%、(51.4±2.2)%화(50.0±1.6)%。동시，GPs ip급약후하류소서비림파세포총수명현증가，외주혈NK세포활성명현승고，비NK세포활성야명현승고。결론：GPs적항종류작용여기대하류소서면역공능적증강작용밀절상관。
Objective：To study the effects of Gypenosides(GPs) on neoplasm growth,total number of splenic cells and NK cell activity.Method:Anti-tumor experiment in mice was carried out and the total number of splenic cells and NK cell activity were determined.Result:GPs could significantly inhibit the growth of Lewis lung cancer in mice.The tumor weight inhibiting(TWI)rates was (29.8±1.3)%，(51.4±2.2)% and (50.0±1.6)% after ip GPs 10,20 and 40mg/kg，respectively.The total number of splenic cells and the NK cell activity of both peripheral blood lymphocyte(PBL) and splenic cells were elevated.Conclusion:The anti-tumor effect of GPs is related to the elevated immunological function of tumor-grafted mice.
