CAJ | 학술논문

目的：观察前列腺素E1(PGE1)对糖尿病周围神经病变的疗效。方法： 65例糖尿病周围神经病变患者随机分组对照观察：前列腺素E1组34例，给予PGE1 200 μg,溶于生理盐水注射液(NS) 500 ml静脉点滴每日一次，共4周；安慰剂组31例，其降糖、降压、降脂及活血化淤等基础治疗与前列腺素E1组相同，另给予生理盐水注射液500 ml静脉点滴每日一次，共4周。结果：前列腺素E1组痛觉过敏及感觉减退有效率达36.8%和65.4%，与安慰剂组相比显著提高(P＜0.05)；神经传导速度改善的有效率也显著提高(P＜0.05)。结论：前列腺素E1对糖尿病周围神经病变具有一定疗效。
목적： 관찰전렬선소E1(PGE1)대당뇨병주위신경병변적료효。방법： 65례당뇨병주위신경병변환자수궤분조대조관찰：전렬선소E1조34례，급여PGE1 200 μg,용우생리염수주사액(NS) 500 ml정맥점적매일일차，공4주；안위제조31례，기강당、강압、강지급활혈화어등기출치료여전렬선소E1조상동，령급여생리염수주사액500 ml정맥점적매일일차，공4주。결과： 전렬선소E1조통각과민급감각감퇴유효솔체36.8%화65.4%，여안위제조상비현저제고(P＜0.05)；신경전도속도개선적유효솔야현저제고(P＜0.05)。결론： 전렬선소E1대당뇨병주위신경병변구유일정료효。
Objective： To investigate the effect of PGE1 on diabetic neuropathies.Methods： 65 patients with diabetic neuropathies were involved in a randomized control clinical trial.34 cases were treated with PGE1 200 μg solved in normal saline (500 ml) intravenously everyday for 4 weeks.31 cases treated with same basic therapy included hypolycemic agent,decompression,blood-lipid lowerring and so on as the PGE1 group except normal saline 500 ml intravenously everyday for 4 weeks.Results： Hyperalgia and hypoesthesia were improved by 36.8% and 65.4% in the PGE1 group,which were increased obviously compared with the placebo,P＜0.05;PGE1 also benefited nerve conduction velocity to a better extent compared with the placebo,P＜0.05.Conclusion: PGE1 could give certain effect on diabetic neuropathies.