CAJ | 학술논문

【目的】比较加味当归芍药散和双益平(石杉碱甲)片剂治疗老年性痴呆(阿尔茨海默病，Alzheimerdisease,AD)的疗效。【方法】35例AD病人随机分为2组，加味当归芍药散组20例，双益平组15例；分别给予加味当归芍药散口服液10mL，口服tid×8周和双益平片剂0.15mg，口服，bid×8周。【结果】与治疗前相比，两组长谷川痴呆量表(HDS-R)积分均有显著性改善(P＜0.05)，但HDS-R积分值分级变化并未显示显著性(P＞0.05)；加味当归芍药散组和双益平组总有效率分别为75%和73.4%，两组比较差异无显著性；但对病人非认知性精神症状(SCAG积分值)的改善加味当归芍药散优于双益平(P＜0.01)。【结论】加味当归芍药散对AD有一定改善作用。
【목적】비교가미당귀작약산화쌍익평(석삼감갑)편제치료노년성치태(아이자해묵병，Alzheimerdisease,AD)적료효。【방법】35례AD병인수궤분위2조，가미당귀작약산조20례，쌍익평조15례；분별급여가미당귀작약산구복액10mL，구복tid×8주화쌍익평편제0.15mg，구복，bid×8주。【결과】여치료전상비，량조장곡천치태량표(HDS-R)적분균유현저성개선(P＜0.05)，단HDS-R적분치분급변화병미현시현저성(P＞0.05)；가미당귀작약산조화쌍익평조총유효솔분별위75%화73.4%，량조비교차이무현저성；단대병인비인지성정신증상(SCAG적분치)적개선가미당귀작약산우우쌍익평(P＜0.01)。【결론】가미당귀작약산대AD유일정개선작용。
【Objective】 To compare the therapeutic effects of modified Danggui Shaoya o Powder (MDSP) and Hup-A Tablet for Alzheimer's disease(AD).【Methods 】 Thirty- five cases of AD were randomly allocated to Group A and Group B.Group A (n=20) w ere treated with MDSP Oral Liquid 10ml per time, p.o. tid for 8 weeks and Group B (n=15)with Hup-A Tablet 0.15mg，p.o.bid for 8 wee ks. 【Re sults】 The scores of HDS-R in the two groups were significantly improved(P＜0.05) but the difference of score ranging was not si gnificant (P＞0.05)as compared with those before treatment. The total effective rate was 75% and 73.4% in Gr o up A and Group B respectively, the differences being not significant(P＞0.05).The effect of MDSP on non-cognitive mental symptoms was superior to Hup-A(P＜0.01).【Conclusion】 MD SP exerts a certain effect on AD.