CAJ | 학술논문

目的评价非小细胞肺癌裸鼠体内肿瘤药物筛选结果及临床应用疗效。方法新鲜非小细胞肺癌组织块植入裸鼠肾包膜下，选用常用抗非小细胞肺癌药物进行肿瘤药敏试验。临床实验组依据肿瘤药敏结果进行肺癌根治术后辅助化学治疗；临床对照组选取同期非小细胞肺癌根治术后接受CAP方案辅助化学治疗。结果人体癌细胞植入裸鼠体内后能很好地保持肿瘤细胞形态，移植瘤细胞可见率为87.8％。临床实验组3 a生存率为60.0％，临床对照组3 a生存率为50.0％，差异无显著性(P>0.05)，两组Ⅲ期3 a生存率分别为52.6％和33.3％，差异有显著性(P<0.05)。结论裸鼠肾包膜下筛选抗肿瘤药物进行术后辅助化疗有非常显著临床效果，3 a生存率有一定提高，避免肿瘤化学治疗上的盲目性。
목적 평개비소세포폐암라서체내종류약물사선결과급림상응용료효。방법신선비소세포폐암조직괴식입라서신포막하，선용상용항비소세포폐암약물진행종류약민시험。림상실험조의거종류약민결과진행폐암근치술후보조화학치료；림상대조조선취동기비소세포폐암근치술후접수CAP방안보조화학치료。결과인체암세포식입라서체내후능흔호지보지종류세포형태，이식류세포가견솔위87.8％。림상실험조3 a생존솔위60.0％，림상대조조3 a생존솔위50.0％，차이무현저성(P>0.05)，량조Ⅲ기3 a생존솔분별위52.6％화33.3％，차이유현저성(P<0.05)。결론라서신포막하사선항종류약물진행술후보조화료유비상현저림상효과，3 a생존솔유일정제고，피면종류화학치료상적맹목성。
Objective To evaluate chemosensitivity of non - small cell lung cancer(NSCLC) in nude mice subrenal capsule as-say and efficacy of adjuvant chemotherapy after radical surgery for NSCLC. Methods Fresh non- small lung cancer specimens weretransplanted into nude mice and 10 kinds of potential anticancer drugs were used in vivo chemosensitivity test. 120 patents with NSCLCundergone radical surgery were randomized into two groups: 70 patients received adjuvant chemotherapy based on chemosensitivity testingin nude mice assay, 50 patients received adjuvant chemotherapy with standard medicines. Results The histological examination showedthat many well preserved tumor cells in nude mice on day 12 and individual lung cancers showed different sensitivities to the drugs. The3 - year survival rate was 60.0% in the nude mice assay group , and 50.0% in the contral group. The difference between two groupswas not statistical significant( P > 0.05). But in stage Ⅲ, the survival rate was 52.6% and 33.3%, with statistically significance( P <0.05). Conclusion The tumor chemosensitivity testing in nude mice assay showed an excellent clinic results, Postoperative adjuvantchemotherapy based on chemosensitivity testing in nude mice assay results in significantly higher 3 - year survival rate in stage Ⅲ than instandard medicines.