中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2000年
4期
195-197
,共3页
宋滇平%王玉明%段勇%杨慧英%赵淮%刘华%杨绍稳%谷燕珊
宋滇平%王玉明%段勇%楊慧英%趙淮%劉華%楊紹穩%穀燕珊
송전평%왕옥명%단용%양혜영%조회%류화%양소은%곡연산
2型糖尿病%胰升糖素受体基因%聚合酶链反应-变性梯度凝胶电泳
2型糖尿病%胰升糖素受體基因%聚閤酶鏈反應-變性梯度凝膠電泳
2형당뇨병%이승당소수체기인%취합매련반응-변성제도응효전영
Type 2 diabetes mellitus Glucagon receptor gene Polymerase chain reaction denaturing gradient gel electrophoresis
目的探讨胰升糖素受体(GCG-R)基因在中国人2 型糖尿病遗传背景中的地位.方法运用聚合酶链反应-变性梯度凝胶电泳(PCR-DGGE)技术对200例无亲缘关系之中国云南昆明地区汉族人(2型糖尿病患者12 0例,健康对照者80例)的GCG-R基因编码区进行了分子扫查.结果仅发现2例2型糖尿病患者及1例健康对照者的GCG-R基因第7外显子存在多态变异带型,这一杂合子多态变异基因型在2型糖尿病组和对照组中的发生频率分别为0.017和0.013,两者之间无显著性差异.此外,研究对象GCG-R基因其它编码区的PCR-DGGE扫查均未发现异常泳动片段.结论 GCG-R基因可能不是中国昆明地区汉族人2型糖尿病的主要致病基因.
目的探討胰升糖素受體(GCG-R)基因在中國人2 型糖尿病遺傳揹景中的地位.方法運用聚閤酶鏈反應-變性梯度凝膠電泳(PCR-DGGE)技術對200例無親緣關繫之中國雲南昆明地區漢族人(2型糖尿病患者12 0例,健康對照者80例)的GCG-R基因編碼區進行瞭分子掃查.結果僅髮現2例2型糖尿病患者及1例健康對照者的GCG-R基因第7外顯子存在多態變異帶型,這一雜閤子多態變異基因型在2型糖尿病組和對照組中的髮生頻率分彆為0.017和0.013,兩者之間無顯著性差異.此外,研究對象GCG-R基因其它編碼區的PCR-DGGE掃查均未髮現異常泳動片段.結論 GCG-R基因可能不是中國昆明地區漢族人2型糖尿病的主要緻病基因.
목적탐토이승당소수체(GCG-R)기인재중국인2 형당뇨병유전배경중적지위.방법운용취합매련반응-변성제도응효전영(PCR-DGGE)기술대200례무친연관계지중국운남곤명지구한족인(2형당뇨병환자12 0례,건강대조자80례)적GCG-R기인편마구진행료분자소사.결과부발현2례2형당뇨병환자급1례건강대조자적GCG-R기인제7외현자존재다태변이대형,저일잡합자다태변이기인형재2형당뇨병조화대조조중적발생빈솔분별위0.017화0.013,량자지간무현저성차이.차외,연구대상GCG-R기인기타편마구적PCR-DGGE소사균미발현이상영동편단.결론 GCG-R기인가능불시중국곤명지구한족인2형당뇨병적주요치병기인.
Objective To probe the role of the glucagon receptor (GCG R) gene in the background of type 2 diabetes mellitus in Chinese.Methods A total of 200 unrelated Chinese subjects (120 patients with type 2 diabetes and 80 nondiabetic control individuals without family history of diabetes) from Kunming were screened for the presence of the polymorphic variants in codon domains of the GCG R gene by use of polymerase chain reaction denaturing gradient gel electrophoresis (PCR DGGE).Results Only a heterozygous polymorphic band was observed in exon 7 in 2 diabetics and 1 control person and no differences in the frequencies of this abnormal conformer were found between diabetic patients and control group.No other abnormal band patterns in codon regions of the GCG R gene were showed in all of the subjects investigated,including type 2 diabetics and controls.Conclusion The results suggested that the GCG R gene is not the causative gene responsible for the occurrence of type 2 diabetes mellitus in Chinese and indicated the genetic heterogeneity of type 2 diabetes mellitus in different ethnic populations.