中国癌症研究(英文版)
中國癌癥研究(英文版)
중국암증연구(영문판)
CHINESE JOURNAL OF CANCER RESEARCH
2002年
1期
76-78
,共3页
何峰%戴颖仪%朱孝峰%黄爱东%张翎%颜少平%刘宗潮
何峰%戴穎儀%硃孝峰%黃愛東%張翎%顏少平%劉宗潮
하봉%대영의%주효봉%황애동%장령%안소평%류종조
Podophyllotoxin analogues%Antitumor activity%Quinolones
Objective: To study the active sites of podophyllotoxin derivatives. Methods: Some podophyllotoxin derivatives were analyzed by quantum and mechanics method. Results: Some information was given according to the calculation results about HOMO and LUMO electron density. The C-4 position is the position for effective modification. The B ring and E ring are important active centers. Conclusion: The hole of positive charge in B ring easily combines with an acceptor within the molecular. Some quinolones with similar electronic construction to podophyllotoxin may have antitumor activity.
