中国癌症研究(英文版)
中國癌癥研究(英文版)
중국암증연구(영문판)
CHINESE JOURNAL OF CANCER RESEARCH
2002年
1期
24-27
,共4页
李贺书%李殿俊%刘旭%李大林
李賀書%李殿俊%劉旭%李大林
리하서%리전준%류욱%리대림
Retrovirus adenovirus%Tumor genetherapy%Ames micronucleus
Objective: To observe the mutagenicity of retrovirus and adenovirus as transgenic vectors to evaluate the safety of transgenic tumor cells as tumor vaccines. Methods: Cells were cultured together with the virus. Then DNA and supernatant were tested for mutagenicity by means of genetic toxicological laboratory technique. Results: The results indicated that DNA and supernatant of transgenic cells had no mutagenicity through both in vivo and in vitro tests. Conclusion: The modified virus had no mutagenicity as a transgenic vector.
