CAJ | 학술논문

目的：探讨转化生长因子β1(TGF-β1)在鼻息肉组织中的表达及意义。方法：将34例鼻息肉标本及30例中鼻甲粘膜标本行TGF-β1免疫组化染色，光镜观察。结果：①TGF-β1在鼻息肉组织的细胞外基质和固有层浸润细胞的表达明显高于中鼻甲组织(P＜0.01)。②鼻息肉组织中TGF-β1阳性细胞的形态及分布相似于嗜酸性粒细胞，二者阳性程度显著相关(P＜0.05)。③TGF-β1阳性表达与鼻息肉的临床分型无关(P＞0.05)，嗜酸性粒细胞浸润程度与鼻息肉临床分型密切相关(P＜0.05)。结论：①TGF-β1可能直接参与鼻息肉的病理变化，导致上皮基底膜增厚和基质纤维化。②嗜酸性粒细胞可能为鼻息肉中TGF-β1的主要来源。③嗜酸性粒细胞在鼻息肉的发病及复发过程中可能发挥重要作用。
목적：탐토전화생장인자β1(TGF-β1)재비식육조직중적표체급의의。방법：장34례비식육표본급30례중비갑점막표본행TGF-β1면역조화염색，광경관찰。결과：①TGF-β1재비식육조직적세포외기질화고유층침윤세포적표체명현고우중비갑조직(P＜0.01)。②비식육조직중TGF-β1양성세포적형태급분포상사우기산성립세포，이자양성정도현저상관(P＜0.05)。③TGF-β1양성표체여비식육적림상분형무관(P＞0.05)，기산성립세포침윤정도여비식육림상분형밀절상관(P＜0.05)。결론：①TGF-β1가능직접삼여비식육적병리변화，도치상피기저막증후화기질섬유화。②기산성립세포가능위비식육중TGF-β1적주요래원。③기산성립세포재비식육적발병급복발과정중가능발휘중요작용。
Objective:To study the expression and significance of transforming growth factor-β1 (TGF-β1) in nasal polyps.Method:Expression of TGF-β1 in nasal polyps from 34 patients and middle turbinates from 30 patients with deviation of nasal septum were prospectively studied with immunohistochemistry.Each tissue section was observed under optical microscope.Result:①The TGF-β1 positivity in extracellular matrix and in cells in the stroma was significantly higher in nasal polyps than in middle turbinates (P＜0.01).②The distribution and shape of TGF-β1 expressing cells in nasal polyps was similar to that of eosinophil,their positivities were significantly correlative (P＜0.05).③The positivity of TGF-β1 did not correlate with clinical type of nasal polyps (P＞0.05),eosinophil infiltration correlated significantly with clinical type of nasal polyps(P＜0.05).Conclusion:①The TGF-β1 may contribute to some of the pathologic changes observed in nasal polyps,such as thickening of the epithelial basement membrane and stromal fibrosis.②Eosinophils in nasal polyps represent a major source of TGF-β1.③Eosinophils infiltration may play a prominent role in the development and recurrence of nasal polyps.